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Flavoproteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Families:   Flavodoxin-related [ 52219] (5)
  Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)
  Quinone reductase [ 52235] (3)
  Hypothetical protein SP1951 [ 102234]
  Hypothetical protein YwqN [ 102237]
  NADPH-dependent FMN reductase [ 89590] (4)
  Flavoprotein NrdI [ 110477]
  WrbA-like [ 117474] (2)


Superfamily statistics
Genomes (3,000) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 23,557 171,867 69
Proteins 23,470 171,398 69


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0000000000002025Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000001761Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4629Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000003249InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000004895InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00004025InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01478Least InformativeInherited
Disease Ontology (DO)organ system cancer0.4104Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.00001437Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.00002115Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0.00008798Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.001426Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.001967Moderately InformativeInherited
Disease Ontology (DO)artery disease0.005037Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02771Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.08311Moderately InformativeInherited
Disease Ontology (DO)brain disease0.2614Moderately InformativeInherited
Disease Ontology (DO)migraine0.00001116InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00006195InformativeDirect
Disease Ontology (DO)asthma0.0001207InformativeDirect
Disease Ontology (DO)nephritis0.0003573InformativeDirect
Disease Ontology (DO)hypertension0.2892InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3352InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.0001018Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.0004261Highly InformativeDirect
Disease Ontology (DO)pre-eclampsia0.0008575Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.02118Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.05289Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05617Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07362Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08388Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1748Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4369Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5831Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.000718Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008915Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0.001111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.00283Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.003567Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.003584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.003603Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.003662Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.005717Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.006121Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.007249Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01284Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01321Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.01919Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02086Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.02892Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.03217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.03806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.04392Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.06528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07248Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.2747Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3852Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.000006884InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.0000257InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.00009486InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0.0001721InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002725InformativeDirect
Mammalian Phenotype (MP)abnormal circulating enzyme level0.0003049InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0003082InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol level0.0004035InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0004973InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0005962InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0006273InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0006612InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.00068InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0009021InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0009265InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.001032InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.001186InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.001503InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.002061InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.002075InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.002391InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.002752InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.006042InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.006467InformativeInherited
Mammalian Phenotype (MP)seizures0.006731InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.008995InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.01065InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.01185InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.01235InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.01345InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.01719InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.02897InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.032InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0324InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.04072InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04319InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.9123InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.0000000002032Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.0000000002032Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000001001Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.00000002767Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0.00000005807Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.00000008784Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.00000008784Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.00000008784Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.0000002492Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.0000003333Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.0000007141Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.0000007926Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.0000009866Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000001329Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.000001459Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.000003422Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.000003522Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.000003779Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.000004976Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.000005615Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.00000793Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.000008369Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.000009342Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0000141Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.00001478Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.00002028Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0.00003732Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.00003732Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.00009958Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001124Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0001319Highly InformativeDirect
Mammalian Phenotype (MP)prenatal lethality, incomplete penetrance0.0001443Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0001612Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0.0002115Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.0002299Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.0003809Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0004549Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.00074Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000001365InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000000000000008194Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0.00001949Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.1703Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Flavoproteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]