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Cytochrome p450 reductase N-terminal domain-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Family:   Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)


Family statistics
Genomes (459) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 693 2,932 7
Proteins 691 2,928 7


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000957Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.07985Least InformativeInherited
Disease Ontology (DO)organ system cancer0.3086Least InformativeInherited
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.0002938Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0007261Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0009358Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001663Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.001986Moderately InformativeInherited
Disease Ontology (DO)artery disease0.002192Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00666Moderately InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.000001567InformativeDirect
Disease Ontology (DO)parasitic infectious disease0.000004415InformativeDirect
Disease Ontology (DO)peripheral nervous system neoplasm0.00009105InformativeDirect
Disease Ontology (DO)asthma0.00009631InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0001013InformativeDirect
Disease Ontology (DO)Alzheimer's disease0.0001305InformativeDirect
Disease Ontology (DO)hypertension0.00045InformativeDirect
Disease Ontology (DO)migraine0.0000003373Highly InformativeDirect
Disease Ontology (DO)ischemia0.00001099Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.00001612Highly InformativeDirect
Disease Ontology (DO)autonomic nervous system neoplasm0.00007885Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Increased blood pressure0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.05777Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0612Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone structure0.000903Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.0012Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.00169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.001756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.002133Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.00349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.005528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.008393Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2719Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2964Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal enzyme/coenzyme level0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal sterol level0InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.00002157InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0000219InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.00002302InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.00002342InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.00003946InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.00004337InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.00004392InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0.00007316InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.00008564InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.00009627InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0.0001273InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton development0.0001641InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0003669InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.0004145InformativeDirect
Mammalian Phenotype (MP)abnormal lipoprotein level0.000427InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.0004334InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0004396InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0004786InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.0009807InformativeDirect
Mammalian Phenotype (MP)seizures0.001304InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.002745InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.003167InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.003366InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.004941InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.007071InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.007341InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.01197InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.02519InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.02596InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.1487InformativeInherited
Mammalian Phenotype (MP)reduced fertility0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0Highly InformativeDirect
Mammalian Phenotype (MP)prenatal lethality, incomplete penetrance0Highly InformativeDirect
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.000000000004719Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.000000000004719Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.00000000002377Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000000003744Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0.00000000148Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.000000001851Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.000000001851Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.000000001851Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.000000004892Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.000000007889Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.00000001202Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.00000001373Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.00000001769Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.00000003108Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.00000003445Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle pressure0.00000004201Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00000007793Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.00000009114Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine osmolality0.00000009859Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.00000009859Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.0000001232Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.0000001323Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.000000224Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.000000224Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.0000002382Highly InformativeDirect
Mammalian Phenotype (MP)abnormal osteoclast physiology0.0000002532Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.0000002843Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0000003739Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.0000004597Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0.0000008382Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.000001205Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.000002634Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.000003638Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.000003838Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.00001067Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart weight0.00003037Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0002774Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)branch0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000005603InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0.0000004441Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]