SUPERFAMILY 1.73 HMM library and genome assignments server


Type II 3-dehydroquinate dehydratase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   Flavodoxin-like [ 52171] (15)
  3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
Superfamily:   Type II 3-dehydroquinate dehydratase [ 52304]
Families:   Type II 3-dehydroquinate dehydratase [ 52305]


Superfamily statistics
Genomes (652) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 734 973 8
Proteins 734 973 8


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR001874 SSF52304 Protein matches
Abstract 3-dehydroquinate dehydratase , or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. Class-II enzymes are homododecameric enzymes of about 17 kDa. They are found in some bacteria such as actinomycetales [PubMed1910148, PubMed8170389] and some fungi where they act in a catabolic pathway that allows the use of quinic acid as a carbon source.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Type II 3-dehydroquinate dehydratase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Type II 3-dehydroquinate dehydratase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]