SUPERFAMILY 1.75 HMM library and genome assignments server

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NADPH-cytochrome p450 reductase-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52342]
Superfamily:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52343] (5)
Family:   NADPH-cytochrome p450 reductase-like [ 52365] (3)


Family statistics
Genomes (716) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 977 5,820 7
Proteins 977 5,819 7


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000001061Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000006862InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.04111Least InformativeInherited
Disease Ontology (DO)organ system cancer0.2245Least InformativeInherited
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.00003222Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.0003693Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0.001232Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.001386Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00258Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.003271Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.005606Moderately InformativeInherited
Disease Ontology (DO)artery disease0.007272Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.02079Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.6249Moderately InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.000006825InformativeDirect
Disease Ontology (DO)parasitic infectious disease0.0000189InformativeDirect
Disease Ontology (DO)asthma0.0003625InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0003826InformativeDirect
Disease Ontology (DO)Alzheimer's disease0.0004961InformativeDirect
Disease Ontology (DO)hypertension0.001636InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3758InformativeInherited
Disease Ontology (DO)migraine0.000001535Highly InformativeDirect
Disease Ontology (DO)ischemia0.00004585Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.00006591Highly InformativeDirect
Disease Ontology (DO)autonomic nervous system neoplasm0.0002962Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1488Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.0223Moderately InformativeInherited
Phenotypic Abnormality (PA)Increased blood pressure0.0005525Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01081Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02909Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.03868Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1099Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1439Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1513Least InformativeInherited
Mammalian Phenotype (MP)abnormal body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.00004447Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.0001056Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0001833Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.0002655Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0006667Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.001055Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.001261Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.001668Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.002044Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.003157Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.00413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.005701Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.00592Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.007108Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.007181Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.007335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01045Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01049Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.01122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.02504Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2719Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2964Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.00000253InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.000008766InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0.00002093InformativeDirect
Mammalian Phenotype (MP)abnormal sterol level0.00002114InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.00003878InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0000864InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.00008783InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.00009202InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.0000935InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.0001553InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0001705InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.0001728InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0.0002817InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0003277InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0003675InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0.0004826InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton development0.0006108InformativeDirect
Mammalian Phenotype (MP)abnormal enzyme/coenzyme level0.0008481InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.0009807InformativeDirect
Mammalian Phenotype (MP)seizures0.001304InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.001485InformativeInherited
Mammalian Phenotype (MP)abnormal lipoprotein level0.001529InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.001566InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.004941InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.007071InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.007341InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.009003InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.01028InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.01085InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.01197InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.02519InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.02596InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.1487InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.00000000002349Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.00000000002349Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.0000000001181Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.000000001829Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0.000000007208Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.000000008964Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.000000008964Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.000000008964Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.0000000234Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.0000000376Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.00000005697Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.00000006474Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.00000008304Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.0000001185Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.0000001449Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.0000001605Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle pressure0.0000001948Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.0000003579Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.0000004188Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine osmolality0.0000004518Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.0000004518Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.0000005604Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.0000006019Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.000001013Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.000001013Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.000001075Highly InformativeDirect
Mammalian Phenotype (MP)abnormal osteoclast physiology0.000001139Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.000001275Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.000001678Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.000002053Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0.000003659Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.000005205Highly InformativeDirect
Mammalian Phenotype (MP)prenatal lethality, incomplete penetrance0.00000697Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.00001129Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.00001547Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.00001633Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.00004038Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.00004379Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart weight0.0001204Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0002774Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)branch0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.00000000001205InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000000000000002552Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ferredoxin reductase-like, C-terminal NADP-linked domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]