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Class I aminoacyl-tRNA synthetases (RS), catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Nucleotidylyl transferase [ 52374] (5)
Family:   Class I aminoacyl-tRNA synthetases (RS), catalytic domain [ 52375] (12)


Family statistics
Genomes (3,260) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,686 262,938 45
Proteins 36,637 262,773 45


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.0002778Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.0176Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.02958Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.03594Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4041Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4089Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size0.001708Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.003833Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.04819Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.04947Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.1177Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2316Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5947Moderately InformativeInherited
Phenotypic Abnormality (PA)Acidosis0.0000005858InformativeDirect
Phenotypic Abnormality (PA)Abnormal liver morphology0.05247InformativeInherited
Phenotypic Abnormality (PA)Hypertonia0.1141InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.4694InformativeInherited
Phenotypic Abnormality (PA)Hepatic steatosis0.0000393Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplasia of the corpus callosum0.0001756Highly InformativeDirect
Phenotypic Abnormality (PA)Spasticity0.0005232Highly InformativeDirect
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.02909Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.317Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00007215Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0006802Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0006802Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0008869Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.02636Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.05757Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0003044Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.002279Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.05768Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.2276Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4835Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5474Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.9277Moderately InformativeInherited
Worm Phenotype (WP)avoids bacterial lawn0.00000003486InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0000005029InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0002584InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.006221InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.009887InformativeInherited
Worm Phenotype (WP)oocyte physiology variant0.03771InformativeInherited
Worm Phenotype (WP)cell stress response variant0.1046InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.15InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.38InformativeInherited
Worm Phenotype (WP)organism stress response variant0.7896InformativeInherited
Worm Phenotype (WP)hypoxia response variant0Highly InformativeDirect
Worm Phenotype (WP)cell differentiation variant0.0000000000001536Highly InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.000000003418Highly InformativeDirect
Worm Phenotype (WP)general pace of development defective early emb0.000182Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.0002524Highly InformativeDirect
Worm Phenotype (WP)paraquat response variant0.0004909Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.9321Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.0481Moderately InformativeInherited
Yeast Phenotype (YP)heat sensitivity0.0008536InformativeDirect
Yeast Phenotype (YP)respiratory metabolism0.005023InformativeInherited
Yeast Phenotype (YP)mitochondrial genome maintenance0.0003635Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)decreased cell size0.00004958Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.000037InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-oxygen bonds0InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 114 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nucleotidylyl transferase domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]