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Adenine nucleotide alpha hydrolases-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Adenine nucleotide alpha hydrolases-like [ 52402] (6)
Families:   N-type ATP pyrophosphatases [ 52403] (8)
  PP-loop ATPase [ 82359] (2)
  PAPS reductase-like [ 52410] (2)
  ETFP subunits [ 52432] (2)
  Universal stress protein-like [ 52436] (7)
  ThiI-like [ 142093] (2)


Superfamily statistics
Genomes (3,265) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 57,962 427,258 38
Proteins 54,215 394,732 38


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0003274Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)tRNA(Ile)-lysidine synthetase0Highly InformativeDirect
Enzyme Commission (EC)tRNA sulfurtransferase0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0.0000002237Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.0613Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.15Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1573Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.625Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.0009274Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.01289Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.04438Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1624Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1896Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.9525Moderately InformativeInherited
Phenotypic Abnormality (PA)Hepatic steatosis0.0003299InformativeDirect
Phenotypic Abnormality (PA)Abnormality of mitochondrial metabolism0.0003428InformativeDirect
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.008385InformativeInherited
Phenotypic Abnormality (PA)Nausea and vomiting0.04654InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.05688InformativeInherited
Phenotypic Abnormality (PA)Vomiting0.0001203Highly InformativeDirect
Phenotypic Abnormality (PA)Coma0.0002154Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.0003677Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.7143Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.01221InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Transferring sulfur-containing groups0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000000001241InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0.000000000000002507Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Adenine nucleotide alpha hydrolases-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Adenine nucleotide alpha hydrolases-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]