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Tubulin nucleotide-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Tubulin nucleotide-binding domain-like [ 52489]
Superfamily:   Tubulin nucleotide-binding domain-like [ 52490]
Families:   Tubulin, GTPase domain [ 52491] (3)


Superfamily statistics
Genomes (3,030) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,893 76,293 19
Proteins 10,801 76,009 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01653Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008681InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00006295Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1614Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.0371Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.05354Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.00002595Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.000193Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000005313Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0000006927Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0003975Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0004998Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.001019Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.001023Least InformativeInherited
Worm Phenotype (WP)cell development variant0.00621Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000000007281Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00000006531Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00001207Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0002621Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.002182Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.009991Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.02399Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.04098Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.09921Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1115Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.1599Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.8422Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9082Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000004424InformativeDirect
Worm Phenotype (WP)nicotine response variant0.00000008456InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000002432InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00006262InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.00008066InformativeDirect
Worm Phenotype (WP)male mating variant0.00009821InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0003342InformativeDirect
Worm Phenotype (WP)mitosis variant0.0003852InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0004227InformativeDirect
Worm Phenotype (WP)cell component localization variant0.003486InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.003813InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.01152InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.01844InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04922InformativeInherited
Worm Phenotype (WP)RNA expression variant0.2736InformativeInherited
Worm Phenotype (WP)egg laying variant0.5194InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6725InformativeInherited
Worm Phenotype (WP)nuclear appearance number defective early emb0.0000000002278Highly InformativeDirect
Worm Phenotype (WP)nucleus defective early emb0.0000000002278Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0000000002278Highly InformativeDirect
Worm Phenotype (WP)pronuclear morphology defective early emb0.0000000002278Highly InformativeDirect
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.0000000002759Highly InformativeDirect
Worm Phenotype (WP)nuclear morphology variation early emb0.0000000003482Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.000000001443Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000000251Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.0000002435Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.0000005346Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000006004Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.00001254Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00001956Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.00002375Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.00004036Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.00007407Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0002348Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000401Highly InformativeDirect
Worm Phenotype (WP)nose touch variant0.0004164Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.002292Highly InformativeInherited
Worm Phenotype (WP)synapse morphology variant0.004903Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.07283Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0002078InformativeDirect
Fly Phenotype (FP)cell cycle defective0.0002559InformativeDirect
Fly Phenotype (FP)male fertile0.000004115Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.03968Least InformativeInherited
Fly Anatomy (FA)somatic cell0.9534Least InformativeInherited
Fly Anatomy (FA)gonad0.003227Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.03497Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.1773Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.00369InformativeInherited
Fly Anatomy (FA)germline cyst0.00608InformativeInherited
Fly Anatomy (FA)male organism0.007623InformativeInherited
Fly Anatomy (FA)neuroblast0.03281InformativeInherited
Fly Anatomy (FA)spermatid0.00004667Highly InformativeDirect
Fly Anatomy (FA)type I neuroblast0.00009002Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.0003644Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.07154Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2077Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2676Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7778Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000009963Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.00407Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.04167Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001059InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0001889InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.001169InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.07687InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.1024InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.1316InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1925InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000004712Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0000000001002Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000002531Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001946Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.001343Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.001651Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.005206Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.01092Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.1936Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0006374InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR003008 SSF52490 Protein matches
Abstract

This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin nucleotide-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Tubulin nucleotide-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]