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Tubulin, GTPase domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Tubulin nucleotide-binding domain-like [ 52489]
Superfamily:   Tubulin nucleotide-binding domain-like [ 52490]
Family:   Tubulin, GTPase domain [ 52491] (3)


Family statistics
Genomes (3,001) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,552 67,153 19
Proteins 9,504 66,940 19


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01355Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0007274InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0000793Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1269Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.02121Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.03743Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the brainstem0.000001421Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.000008226Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000004093Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.001693Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.003593Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.003593Least InformativeInherited
Worm Phenotype (WP)cell development variant0.01322Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000000004665Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0000003536Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00005802Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004719Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0007057Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.007369Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.02258Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.08731Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1043Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.3297Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.8271Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000151InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.000008668InformativeDirect
Worm Phenotype (WP)spindle variant0.0001634InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001662InformativeDirect
Worm Phenotype (WP)mitosis variant0.0003374InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000813InformativeDirect
Worm Phenotype (WP)cell component localization variant0.003901InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.01033InformativeInherited
Worm Phenotype (WP)gonad development variant0.01107InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04406InformativeInherited
Worm Phenotype (WP)RNA expression variant0.252InformativeInherited
Worm Phenotype (WP)egg laying variant0.5208InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6426InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.000000001015Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance number defective early emb0.000000001072Highly InformativeDirect
Worm Phenotype (WP)nucleus defective early emb0.000000001072Highly InformativeDirect
Worm Phenotype (WP)pronuclear morphology defective early emb0.000000001072Highly InformativeDirect
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.000000001261Highly InformativeDirect
Worm Phenotype (WP)nuclear morphology variation early emb0.000000001477Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.0000005377Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00000146Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.00003425Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00003645Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00008024Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.000116Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0001608Highly InformativeDirect
Worm Phenotype (WP)cuticle morphology variant0.0003052Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0003347Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0005879Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.00085Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.002547Highly InformativeInherited
Worm Phenotype (WP)synapse morphology variant0.004828Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.0557Moderately InformativeInherited
Fly Phenotype (FP)cell cycle defective0.0002391InformativeDirect
Fly Phenotype (FP)wild-type0.000245InformativeDirect
Fly Phenotype (FP)male fertile0.000003775Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.0398Least InformativeInherited
Fly Anatomy (FA)somatic cell0.9472Least InformativeInherited
Fly Anatomy (FA)gonad0.002813Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.02745Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.002492InformativeInherited
Fly Anatomy (FA)male organism0.006449InformativeInherited
Fly Anatomy (FA)somatic stem cell0.2577InformativeInherited
Fly Anatomy (FA)spermatid0.00003165Highly InformativeDirect
Fly Anatomy (FA)type I neuroblast0.00007457Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.0002754Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.02923Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.07802Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.09383Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7579Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000006051Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.001201Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.02721Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001407InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00007874InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0006686InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.08776InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.182InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000002759Highly InformativeDirect
Xenopus ANatomical entity (XAN)ciliated cell0.0000000000000485Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.00000000008465Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000003816Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.000005728Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001527Highly InformativeDirect
Xenopus ANatomical entity (XAN)archenteron0.001214Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.008946Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)vascular system0.006386InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Tubulin nucleotide-binding domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]