SUPERFAMILY 1.75 HMM library and genome assignments server

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G proteins family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Family:   G proteins [ 52592] (78)


Family statistics
Genomes (3,263) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 79,090 417,982 261
Proteins 77,987 410,704 260


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0000000000002694Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0Highly InformativeDirect
Enzyme Commission (EC)Adenylyl-sulfate kinase0.0000000000155Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.1475Moderately InformativeInherited
Mode of Inheritance (MI)Somatic mosaicism0.000002332Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.00126Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.01526Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.048Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.08188Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1661Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.5201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8699Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.007456Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.009601Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.01164Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.04401Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.0669Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.1136Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.5729Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.9129Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.002093InformativeInherited
Phenotypic Abnormality (PA)Abnormal cerebellum morphology0.002762InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.00941InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.05945InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.07381InformativeInherited
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0.1974InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood ion concentration0.2041InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.3282InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.3359InformativeInherited
Phenotypic Abnormality (PA)Visual impairment0.6778InformativeInherited
Phenotypic Abnormality (PA)Precocious puberty0.00007974Highly InformativeDirect
Phenotypic Abnormality (PA)Nystagmus0.0001373Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the optic disc0.0003303Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the cerebellar vermis0.001757Highly InformativeInherited
Phenotypic Abnormality (PA)Visual field defect0.01824Highly InformativeInherited
Phenotypic Abnormality (PA)Nevus0.01976Highly InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the inner ear0.03764Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal location of ears0.1561Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the rib cage0.174Highly InformativeInherited
Phenotypic Abnormality (PA)Reduced visual acuity0.5149Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.3828Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6885Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7245Least InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.164Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.398Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.4125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.04308InformativeInherited
Mammalian Phenotype (MP)abnormal neurotransmitter secretion0.0002597Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000000002253Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00001255Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00003499Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00005945Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0002728Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0002728Least InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000005481Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000005481Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0000005627Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0000005776Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0000008504Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.0002555Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0004181Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0004635Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0005151Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.00224Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.01021Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.01068Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.02043Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.03849Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.06598Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.06894Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.08346Moderately InformativeInherited
Worm Phenotype (WP)tail bend angle variant0.0000000000003094InformativeDirect
Worm Phenotype (WP)head movement variant0.000000000003317InformativeDirect
Worm Phenotype (WP)body bend variant0.0000000002435InformativeDirect
Worm Phenotype (WP)body posture variant0.000000003065InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0000001909InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0000007535InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.00000225InformativeDirect
Worm Phenotype (WP)fat content variant0.00005352InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.00008438InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.0001573InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001743InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0001974InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.007648InformativeInherited
Worm Phenotype (WP)directionality variant0.01111InformativeInherited
Worm Phenotype (WP)spindle variant0.01311InformativeInherited
Worm Phenotype (WP)tail morphology variant0.0753InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.164InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.2157InformativeInherited
Worm Phenotype (WP)cell number increased0.6478InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.8793InformativeInherited
Worm Phenotype (WP)locomotion reduced0.9657InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0.000000000000007785Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.000000000004135Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.00000001234Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.000001182Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.00000123Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.000001243Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.000002143Highly InformativeDirect
Worm Phenotype (WP)fat0.000003746Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.00002434Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.000107Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.0001281Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.0001674Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0002691Highly InformativeDirect
Worm Phenotype (WP)excretory secretory system development variant0.001396Highly InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.04549Highly InformativeInherited
Worm Phenotype (WP)pathogen resistance increased0.1366Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)intracellular transport0.06889InformativeInherited
Yeast Phenotype (YP)autophagy0.0007026Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.3187Moderately InformativeInherited
Fly Phenotype (FP)immune response defective0.00007656InformativeDirect
Fly Phenotype (FP)size defective0.02844InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2247Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4997Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.7714Least InformativeInherited
Fly Anatomy (FA)adult0.9165Least InformativeInherited
Fly Anatomy (FA)segment0.9712Least InformativeInherited
Fly Anatomy (FA)tagma1Least InformativeInherited
Fly Anatomy (FA)epithelium0.2009Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2826Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.4093Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.4987Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7398Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.7614Moderately InformativeInherited
Fly Anatomy (FA)appendage0.7623Moderately InformativeInherited
Fly Anatomy (FA)anatomical space0.0003912InformativeDirect
Fly Anatomy (FA)embryonic/larval tracheal system0.037InformativeInherited
Fly Anatomy (FA)epithelial tube0.1732InformativeInherited
Fly Anatomy (FA)cuticle0.3522InformativeInherited
Fly Anatomy (FA)embryonic/larval trachea0.0007557Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.03484Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.1009Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2516Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.4683Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.5825Least InformativeInherited
Xenopus ANatomical entity (XAN)germ cell0.02533Moderately InformativeInherited
Xenopus ANatomical entity (XAN)testis0.127Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.5978Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.8687InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.6109Highly InformativeInherited
Xenopus ANatomical entity (XAN)olfactory system0.9547Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.001652Least InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.00002091Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0.0008379Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0.0155Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.3334Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5373Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.0000128InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.000000000001246Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]