SUPERFAMILY 1.75 HMM library and genome assignments server

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ABC transporter ATPase domain-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Family:   ABC transporter ATPase domain-like [ 52686] (23)


Family statistics
Genomes (3,249) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 142,770 1,114,003 55
Proteins 131,565 1,062,326 55


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2593Least InformativeInherited
Disease Ontology (DO)organ system cancer0.4139Least InformativeInherited
Disease Ontology (DO)genetic disease0.002516Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1263Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.225Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.2447Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.4937Moderately InformativeInherited
Disease Ontology (DO)myeloid leukemia0.000834InformativeDirect
Disease Ontology (DO)liver disease0.8657InformativeInherited
Disease Ontology (DO)bronchiectasis0.00002649Highly InformativeDirect
Disease Ontology (DO)acute myeloid leukemia0.0000498Highly InformativeDirect
Disease Ontology (DO)leukodystrophy0.0001004Highly InformativeDirect
Disease Ontology (DO)brucellosis0.0001115Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.0002477Highly InformativeDirect
Disease Ontology (DO)cholangitis0.1994Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.002701Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.004136Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1033Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3314Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7107Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8316Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8919Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.02924Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2209Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.2589Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.297Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.4915Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.7282Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.7667Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.9477Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.01165InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uterus0.0135InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.1288InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.1463InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.2199InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.2437InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.3045InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.5764InformativeInherited
Phenotypic Abnormality (PA)Anemia0.6218InformativeInherited
Phenotypic Abnormality (PA)Recurrent acute respiratory tract infection0.0000298Highly InformativeDirect
Phenotypic Abnormality (PA)Endometrial carcinoma0.0002884Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.0003493Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the astrocytes0.0003493Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.002082Highly InformativeInherited
Phenotypic Abnormality (PA)Poikilocytosis0.01965Highly InformativeInherited
Phenotypic Abnormality (PA)Hypertrichosis0.04591Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal eyelash morphology0.1244Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4246Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6811Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.9153Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00009407Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.01411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2119Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.5987Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.02105InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.03767InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.08099InformativeInherited
Mammalian Phenotype (MP)abnormal sterol level0.332InformativeInherited
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.0000000013Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.00002423Highly InformativeDirect
Mammalian Phenotype (MP)nervous system inclusion bodies0.0001139Highly InformativeDirect
Mammalian Phenotype (MP)amyloidosis0.0004566Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0008158Highly InformativeDirect
Mammalian Phenotype (MP)abnormal DNA repair0.01409Highly InformativeInherited
Mammalian Phenotype (MP)increased reproductive system tumor incidence0.02918Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.1332Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2811Least InformativeInherited
Worm Phenotype (WP)cell development variant0.8487Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.04774Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1989Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4553Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.6421Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.7758Moderately InformativeInherited
Worm Phenotype (WP)metal response variant0.0000002194InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.00001392InformativeDirect
Worm Phenotype (WP)drug hypersensitive0.02926InformativeInherited
Worm Phenotype (WP)mitosis variant0.3886InformativeInherited
Worm Phenotype (WP)RNAi resistant0.000003065Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.00004222Highly InformativeDirect
Worm Phenotype (WP)intestinal development variant0.2306Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root1Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0000776InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Translocases0InformativeDirect
Enzyme Commission (EC)Catalysing the translocation of inorganic cations1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]