SUPERFAMILY 1.73 HMM library and genome assignments server


(Phosphotyrosine protein) phosphatases II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   (Phosphotyrosine protein) phosphatases II [ 52798]
  core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
Superfamily:   (Phosphotyrosine protein) phosphatases II [ 52799] (5)
Families:   Dual specificity phosphatase-like [ 52800] (8)
  Higher-molecular-weight phosphotyrosine protein phosphatases [ 52805] (6)
  has an extension to the beta-sheet of 3 antiparallel strands before strand 4
  Myotubularin-like phosphatases [ 102422]
  common fold is decorated with additional structures
  Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA [ 117583]
  Mycobacterial PtpB-like [ 142348]


Superfamily statistics
Genomes (795) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 14,908 6,926 62
Proteins 13,274 6,351 59


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Phosphotyrosine protein) phosphatases II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the (Phosphotyrosine protein) phosphatases II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]