SUPERFAMILY 1.75 HMM library and genome assignments server

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Higher-molecular-weight phosphotyrosine protein phosphatases family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   (Phosphotyrosine protein) phosphatases II [ 52798]
Superfamily:   (Phosphotyrosine protein) phosphatases II [ 52799] (5)
Family:   Higher-molecular-weight phosphotyrosine protein phosphatases [ 52805] (6)


Family statistics
Genomes (487) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,163 22,343 43
Proteins 5,625 17,443 42


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.3864Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.7231Least InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1603Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.2168Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3431Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.5814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.008476InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell number0.01532InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.03057InformativeInherited
Mammalian Phenotype (MP)increased mature B cell number0.000893Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.005203Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.06292Least InformativeInherited
Fly Anatomy (FA)larva0.1191Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0000211Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0.01035Moderately InformativeInherited
Fly Anatomy (FA)nerve0.005045InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.01096InformativeInherited
Fly Anatomy (FA)intersegmental nerve0.000002121Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.08785Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.2842Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3264Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.648Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.235Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2839Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.3803InformativeInherited
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.00005777Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0006537Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 77 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a (Phosphotyrosine protein) phosphatases II domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]