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Glutathione peroxidase-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Family:   Glutathione peroxidase-like [ 52901] (28)


Family statistics
Genomes (2,998) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,418 62,969 65
Proteins 10,411 62,950 65


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.4604InformativeInherited
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.006577Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00236Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.2411Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.001056InformativeInherited
Disease Ontology (DO)Parkinson's disease0.0001013Highly InformativeDirect
Disease Ontology (DO)adenoma0.0001742Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00631Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.339Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.000179Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.8828Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.8828Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2813Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.005052InformativeInherited
Worm Phenotype (WP)cell stress response variant0.009678InformativeInherited
Worm Phenotype (WP)paraquat response variant0.0001121Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.8247Least InformativeInherited
Yeast Phenotype (YP)oxidative stress resistance0.0001384InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)stress response defective0.0001033Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.05223Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.0604Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1072Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.1884Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1966Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.3905Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.5457Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7447Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.00364Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.04323Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.05384Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.05915Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2477Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2552Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail0.0003711InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00263InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.002936InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.01615InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.01688InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.02212InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.02351InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.09455InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.000001189Highly InformativeDirect
Xenopus ANatomical entity (XAN)splanchnocranium0.00001277Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00004032Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00007547Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0002682Highly InformativeDirect
Xenopus ANatomical entity (XAN)bone element0.0006501Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.0006933Highly InformativeDirect
Xenopus ANatomical entity (XAN)skeletal tissue0.0007067Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0009382Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.002097Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0.03878InformativeInherited
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.001147Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 489 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]