SUPERFAMILY 1.75 HMM library and genome assignments server

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Actin/HSP70 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Family:   Actin/HSP70 [ 53068] (7)


Family statistics
Genomes (3,168) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,399 196,835 106
Proteins 19,445 110,209 53


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.004872Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.01913Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02087Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.03161Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.03456Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.03932Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.04371Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.08808Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.0005043Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.0652Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.2119Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.2396Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2624Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.3403Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.3578Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.007697InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.0109InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.01918InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fontanelles or cranial sutures0.09451InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.1913InformativeInherited
Phenotypic Abnormality (PA)Hydroureter0.00001963Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.0003085Highly InformativeDirect
Phenotypic Abnormality (PA)Short neck0.0003957Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal gastrointestinal motility0.0004379Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal jaw morphology0.0004689Highly InformativeDirect
Phenotypic Abnormality (PA)Stroke0.0005446Highly InformativeDirect
Phenotypic Abnormality (PA)Large fontanelles0.0009251Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.438Least InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.03702InformativeInherited
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0006055Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00000001129Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000006548Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000002867Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.000002867Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00001859Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000225Least InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0000000004736Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.0000004337Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.00002424Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0002067Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.003728Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.06165Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.1156Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2352Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.0000006683InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000001303InformativeDirect
Worm Phenotype (WP)brood size variant0.000003306InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000008923InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0004252InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0008971InformativeDirect
Worm Phenotype (WP)vulva morphology variant0.001653InformativeInherited
Worm Phenotype (WP)cell component localization variant0.003937InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.01619InformativeInherited
Worm Phenotype (WP)metal response variant0.04128InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.05139InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.06653InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.0805InformativeInherited
Worm Phenotype (WP)egg laying variant0.5288InformativeInherited
Worm Phenotype (WP)protein expression reduced0.0000287Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.00008817Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.0003Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0004209Highly InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0004454Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb0.0007609Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)morphology0.05343Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.6388InformativeInherited
Yeast Phenotype (YP)freeze-thaw resistance0.0009183Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.005799Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.01598Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.02472Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.102Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.005135Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.04516Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.08977Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.00007998InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0005958InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.003292InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.004795InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.00009706Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.0008098Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.002091Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0001219InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.01783InformativeInherited
Plant ANatomical entity (PAN)trichome0.0002303Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.0000008126InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000006498InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0.00000003632InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 190 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]