SUPERFAMILY 1.75 HMM library and genome assignments server

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DnaQ-like 3'-5' exonuclease family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Ribonuclease H-like [ 53098] (14)
Family:   DnaQ-like 3'-5' exonuclease [ 53118] (15)


Family statistics
Genomes (2,338) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,962 54,589 53
Proteins 7,959 54,576 53


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0.9952InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.00000001254Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease H0.00000004468Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoeste0.00008029Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.05353Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.07697Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4817Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.006165Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.05019Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.01115InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.2832InformativeInherited
Phenotypic Abnormality (PA)Telangiectasia0.0001028Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.1351Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02917Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.004436InformativeInherited
Mammalian Phenotype (MP)increased gland tumor incidence0.009785InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.01005InformativeInherited
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0001522Highly InformativeDirect
Mammalian Phenotype (MP)increased sarcoma incidence0.0004596Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1256Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.1256Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.2201Least InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.0419Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000641InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0002431Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.06273InformativeInherited
Yeast Phenotype (YP)mutation frequency0.00003403Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.002946Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 88 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ribonuclease H-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]