SUPERFAMILY 1.75 HMM library and genome assignments server

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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,591) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,043 178,602 53
Proteins 30,084 163,191 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.04564Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.2231Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4872Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0009268InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01542InformativeInherited
Disease Ontology (DO)bullous skin disease0.01544InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0003545Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1987Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5422Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.677Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6843Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.7926Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02732Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.08013Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.2433Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.28Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.4497Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.5006Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.5146Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.6395Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.6727Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9442Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal tendon morphology0.05805InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.06487InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.07304InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.1107InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.1268InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1525InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.2116InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.2906InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.5362InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.5783InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7796InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.002927Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the diaphragm0.005674Highly InformativeInherited
Phenotypic Abnormality (PA)Strabismus0.06666Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ilium0.1294Highly InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.1447Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.155Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.3521Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1557Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4334Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4468Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.3911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002825InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001599Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0003Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)muscle attachment variant0.00008845Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.08852Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3389Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.1127Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1956Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.6516Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.007508InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.03846InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.07211InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000000000000005946Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000002806Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000000008269Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.02127Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.08182Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000006945InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000000001806InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]