SUPERFAMILY 1.75 HMM library and genome assignments server

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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,591) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,043 178,602 53
Proteins 30,084 163,191 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.04567Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.223Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4871Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0009281InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01543InformativeInherited
Disease Ontology (DO)bullous skin disease0.01545InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0003548Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.3272Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4383Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6922Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7525Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.793Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.04357Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1225Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1922Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1979Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.5394Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.5413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.5786Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.6064Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.6488Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.6814Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9213Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.9295Moderately InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.01598InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.04638InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.05188InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.06484InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1216InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1426InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.3272InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.3659InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.6105InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.8629InformativeInherited
Phenotypic Abnormality (PA)Proximal amyotrophy0.0005042Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.002002Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber protein expression0.004735Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ankles0.01326Highly InformativeInherited
Phenotypic Abnormality (PA)Strabismus0.04717Highly InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.127Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.1629Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1559Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4326Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4472Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3619Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.3911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002823InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001593Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0003009Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)muscle attachment variant0.00009431Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2045Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3134Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.104Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.237Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.6084Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.006952InformativeInherited
Fly Anatomy (FA)tracheal system0.01684InformativeInherited
Fly Anatomy (FA)epithelial tube0.0368InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.05236InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.06858InformativeInherited
Fly Anatomy (FA)primary trachea0.0009545Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000000000000004014Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000001715Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000000008682Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.02304Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.08164Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000006845InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000000001957InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]