SUPERFAMILY 1.75 HMM library and genome assignments server

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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,591) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,043 178,602 53
Proteins 30,084 163,191 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.04567Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.223Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4871Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0009281InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01543InformativeInherited
Disease Ontology (DO)bullous skin disease0.01545InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0003548Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.2605Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4804Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6752Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7735Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.8299Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.0314Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.09763Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1708Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2223Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.5124Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.5247Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.5343Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.5398Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.7177Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.731Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8985Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9298Moderately InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.0141InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.042InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.05264InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.06764InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.102InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1241InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.3081InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.327InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.6677InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.8268InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.001828Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber protein expression0.004876Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ankles0.01129Highly InformativeInherited
Phenotypic Abnormality (PA)Strabismus0.07471Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ilium0.1303Highly InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.1363Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.1608Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.3666Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1556Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.433Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4467Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3619Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.3907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002827InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001595Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0003006Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)muscle attachment variant0.00009345Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1938Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3427Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.1122Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1981Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.6286Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.007525InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.04006InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.05854InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000000000000003998Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000001763Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000000008446Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.02333Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.08203Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000007004InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000000001877InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]