SUPERFAMILY 1.75 HMM library and genome assignments server

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Integrin A (or I) domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Family:   Integrin A (or I) domain [ 53301] (10)


Family statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,208 7,038 46
Proteins 2,132 6,843 46


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)integumentary system disease0.02889Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1187Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1379Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5227Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.000965InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.002086InformativeInherited
Disease Ontology (DO)bullous skin disease0.01141InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.5869InformativeInherited
Disease Ontology (DO)thrombocytopenia0.00003044Highly InformativeDirect
Disease Ontology (DO)Crohn's disease0.0009322Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.005335Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1455Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7278Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.758Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7877Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.7902Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.007246Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03382Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.0346Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.04581Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.05523Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.08296Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.2285Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.4088Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.4243Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5476Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.5897Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.8283Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.002241InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.00508InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.04494InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.09654InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1212InformativeInherited
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0.1911InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.2308InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.3961InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.3998InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.59InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.0001788Highly InformativeDirect
Phenotypic Abnormality (PA)Focal dystonia0.0003382Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.0004043Highly InformativeDirect
Phenotypic Abnormality (PA)Proximal muscle weakness0.005016Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.03535Highly InformativeInherited
Phenotypic Abnormality (PA)Joint laxity0.08446Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal thumb morphology0.0902Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.09103Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.1417Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.4001Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1137Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1141Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3572Least InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.2433Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4328Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.01957InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.00004982Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.8895Least InformativeInherited
Worm Phenotype (WP)movement variant0.3957Moderately InformativeInherited
Worm Phenotype (WP)locomotion reduced0.06507InformativeInherited
Worm Phenotype (WP)paralyzed0.0006707Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]