SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Pancreatic lipase, N-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Family:   Pancreatic lipase, N-terminal domain [ 53577]


Family statistics
Genomes (126) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,723 5,118 6
Proteins 1,657 4,948 6


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Triacylglycerol lipase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.01591Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.00007114InformativeDirect
Disease Ontology (DO)atherosclerosis0.0007402InformativeDirect
Disease Ontology (DO)coronary artery disease0.0007833InformativeDirect
Disease Ontology (DO)pancreatitis0.00001706Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1333Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.01598Moderately InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.01704Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00001067Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipoprotein level0.003551InformativeInherited
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.04846InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.05731InformativeInherited
Mammalian Phenotype (MP)abnormal sterol level0.1166InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0.2222InformativeInherited
Mammalian Phenotype (MP)increased circulating triglyceride level0.000001479Highly InformativeDirect

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.0000015Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.2204Least InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.008417Moderately InformativeInherited
Fly Anatomy (FA)ganglion mother cell0.0004337InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 255 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]