SUPERFAMILY 1.75 HMM library and genome assignments server

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Papain-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Family:   Papain-like [ 54002] (25)


Family statistics
Genomes (917) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,906 24,566 61
Proteins 7,826 24,230 61


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0.01757Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.07282Moderately InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.1776Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2911Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5413Least InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.1264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1269Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3119Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.5038Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.00671InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.008649InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.01021InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.04977InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.09863InformativeInherited
Mammalian Phenotype (MP)abnormal thyroid hormone level0.00004Highly InformativeDirect
Mammalian Phenotype (MP)amyloidosis0.00007084Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thyroid gland morphology0.00007942Highly InformativeDirect
Mammalian Phenotype (MP)thick epidermis0.0002717Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.0005159Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0003301Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0000000000008982Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.000000002653Moderately InformativeDirect
Worm Phenotype (WP)hypoosmotic shock hypersensitive0.0000000003959Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)endocrine system0.0002807InformativeDirect
Xenopus ANatomical entity (XAN)thymus0.0001273Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 116 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]