SUPERFAMILY 1.75 HMM library and genome assignments server

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Calpain large subunit, catalytic domain (domain II) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Family:   Calpain large subunit, catalytic domain (domain II) [ 54040]


Family statistics
Genomes (337) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,147 6,042 10
Proteins 2,125 6,004 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0Moderately InformativeDirect
Disease Ontology (DO)overnutrition0.0002989InformativeDirect
Disease Ontology (DO)myopathy1InformativeInherited
Disease Ontology (DO)muscular dystrophy0.000002239Highly InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.1327Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1536Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.1536Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6122Least InformativeInherited
Worm Phenotype (WP)cell death variant0.0003022Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.01279Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.04491Moderately InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.00001859InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00003259InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0001824InformativeDirect
Worm Phenotype (WP)hypoosmotic shock hypersensitive0.0000001227Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000001447Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 116 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]