SUPERFAMILY 1.75 HMM library and genome assignments server

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Transglutaminase core family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Family:   Transglutaminase core [ 54044] (2)


Family statistics
Genomes (398) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,304 3,919 10
Proteins 1,286 3,884 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptid0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)integumentary system disease0.0001079Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.005426Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.005763Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.00000001976InformativeDirect
Disease Ontology (DO)bullous skin disease0.00000007109InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0001915InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.1751Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.07097Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2786Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.001903InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.1903InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the common coagulation pathway0.00003257Highly InformativeDirect

Document: HP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0002366Least InformativeDirect
Enzyme Commission (EC)Transferases0.0004004Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.000000000000001824Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)In linear amides0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 116 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]