SUPERFAMILY 1.73 HMM library and genome assignments server


His-Me finger endonucleases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (334)
  Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold:   His-Me finger endonucleases [ 54059]
  core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
Superfamily:   His-Me finger endonucleases [ 54060] (6)
Families:   Endonuclease I [ 102726]
  HNH-motif [ 54061] (2)
  Sm endonuclease [ 54066]
  the core motif is inserted in a six-stranded meander beta-sheet domain
  Intron-encoded homing endonucleases [ 54069] (2)
  Recombination endonuclease VII, N-terminal domain [ 68915]
  Caspase-activated DNase, CAD (DffB, DFF40) [ 110778]


Superfamily statistics
Genomes (632) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 2,856 2,129 20
Proteins 2,803 2,057 20


Functional annotation
General category Information
Detailed category DNA replication/repair

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a His-Me finger endonucleases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the His-Me finger endonucleases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]