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Urease, gamma-subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (334)
  Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold:   Urease, gamma-subunit [ 54110]
  alpha(3)-beta(2); antiparallel hairpin
Superfamily:   Urease, gamma-subunit [ 54111]
Families:   Urease, gamma-subunit [ 54112]

 Superfamily statistics
Genomes (433) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 492 626 3
Proteins 492 626 3

 Functional annotation
General category Metabolism
Detailed category Other enzymes

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR002026 SSF54111 Protein matches
Abstract

Urease is a nickel-binding enzyme that catalyzes the hydrolysis of urea to carbon dioxide and ammonia [PubMed3402446]: Urea + H2O = CO2 + 2 NH3 Historically, it was the first enzyme to be crystallized (in 1926). It is mainly found in plantseeds and microorganisms. In plants, urease is a hexamer of identical chains. In bacteria [PubMed2651866], it consists of either two or three different subunits (alpha , beta and gamma, described in this entry). The structure of the urease complex is known [PubMed7754395].

This subunit does not appear to take part in the catalytic mechanism.

InterPro database
PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Urease, gamma-subunit domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Urease, gamma-subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2001-2010 The Medical Research Council and the SUPERFAMILY authors; Derek Wilson, Martin Madera and Julian Gough.