HIT-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (334)
  • Mainly antiparallel beta sheets (segregated alpha and beta regions)
• Fold: HIT-like [ 54196] (2)
  • alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
• Superfamily: HIT-like [ 54197] (3)
• Families:
  • HIT (HINT, histidine triad) family of protein kinase-interacting proteins [ 54198] (6)
    • Pfam 01230
      topologically similar to the N-terminal domain of protein kinases
  • Hexose-1-phosphate uridylyltransferase [ 54207]
    • duplication: consists of 2 HIT-like motifs
      binds zinc and iron ions
  • mRNA decapping enzyme DcpS C-terminal domain [ 102745]

---

Superfamily statistics

	Genomes (1,224)	UniProt 15.0	PDB chains (SCOP 1.73)
Domains	4,847	4,319	22
Proteins	4,328	3,826	17

---

Functional annotation

• General category: Metabolism
• Detailed category: Carbohydrate metabolism and transport

Function annotation of SCOP domain superfamilies

---

InterPro annotation

• Cross references: IPR011146 SSF54197 Protein matches
• Abstract:

  The histidine triad motif (HIT) is related to the sequence H-phi-H-phi-H-phi-phi (where phi is a hydrophobic amino acid). Proteins containing HIT domains form a superfamily of nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides [12119013]. HIT-containing proteins fall into three families:

  • Hint family of protein kinase-interacting proteins. These include adenosine 5'-monophosphoramide hydrolases (e.g. HIT-nucleotide-binding protein, or HINT) and diadenosine polyphosphate hydrolases (e.g. fragile HIT protein, or FINT). These HIT domains have a topology similar to that found in the N-terminal of protein kinases [15904496].
  • GalT family. These include specific nucleoside monophosphate transferases (e.g. galactose-1-phosphate uridylyltransferase, diadenosine tetraphosphate phosphorylase, and adenylyl sulphate:phosphate adenylytransferase). These HIT domains are a duplication consisting of 2 HIT-like motifs. This family binds zinc and iron.
  • mRNA decapping enzyme family. These include enzymes such as DcpS and Dcp2. The HIT-domain is usually C-terminal in these proteins [15273322].

InterPro database

---