SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


DNA gyrase/MutL, second domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ribosomal protein S5 domain 2-like [ 54210]
Superfamily:   Ribosomal protein S5 domain 2-like [ 54211] (12)
Family:   DNA gyrase/MutL, second domain [ 54224] (6)


Family statistics
Genomes (3,215) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,856 58,396 13
Proteins 5,856 58,396 13


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.163Least InformativeInherited
Disease Ontology (DO)genetic disease0.006932Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.06549Moderately InformativeInherited
Disease Ontology (DO)male reproductive organ cancer0.0001106InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.0001629InformativeDirect
Disease Ontology (DO)large intestine cancer0.0009677InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.08773Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.09234Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1181Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1426Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1446Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7718Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.004804Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.006311Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.006456Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.00794Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.008791Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.009164Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01001Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.01056Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.01189Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.01542Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.01723Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.01875Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.02006Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.02104Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.02495Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.03626Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.03824Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.06609Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.08509Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.00000005014InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ovary0.000007495InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.0000101InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.00001863InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.00002367InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.00007061InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.00007223InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.00007615InformativeDirect
Phenotypic Abnormality (PA)Nausea and vomiting0.0001092InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.0001318InformativeDirect
Phenotypic Abnormality (PA)Impairment in personality functioning0.0002615InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0.0003752InformativeDirect
Phenotypic Abnormality (PA)Flexion contracture0.0005387InformativeDirect
Phenotypic Abnormality (PA)Pain0.0007113InformativeDirect
Phenotypic Abnormality (PA)Abnormal intestine morphology0.0007405InformativeDirect
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.001865InformativeInherited
Phenotypic Abnormality (PA)Visual impairment0.002249InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.00353InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.004407InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02675InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uterus0.06206InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.00000000003549Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.0000000001802Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.0000000004902Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000000007563Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000000001359Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.000000001628Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.000000002697Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the rectum0.000000003158Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000000003671Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastoma0.000000003671Highly InformativeDirect
Phenotypic Abnormality (PA)Basal cell carcinoma0.000000007395Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.00000001368Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.00000003175Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.00000003836Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.0000000459Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00000005014Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00000005963Highly InformativeDirect
Phenotypic Abnormality (PA)Endometrial carcinoma0.0000001088Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.0000002115Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.0000003078Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.0000005412Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0000006709Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0000007384Highly InformativeDirect
Phenotypic Abnormality (PA)Hallucinations0.0000007763Highly InformativeDirect
Phenotypic Abnormality (PA)Irritability0.0000008971Highly InformativeDirect
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.000001033Highly InformativeDirect
Phenotypic Abnormality (PA)Visual field defect0.000001824Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.000001901Highly InformativeDirect
Phenotypic Abnormality (PA)Hemiplegia/hemiparesis0.000004183Highly InformativeDirect
Phenotypic Abnormality (PA)Malabsorption0.000004631Highly InformativeDirect
Phenotypic Abnormality (PA)Developmental regression0.00001564Highly InformativeDirect
Phenotypic Abnormality (PA)Anxiety0.00001773Highly InformativeDirect
Phenotypic Abnormality (PA)Abdominal pain0.00002107Highly InformativeDirect
Phenotypic Abnormality (PA)Constipation0.00002154Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.0000266Highly InformativeDirect
Phenotypic Abnormality (PA)Depressivity0.00002784Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pyramidal sign0.00003249Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.00006713Highly InformativeDirect
Phenotypic Abnormality (PA)Dysarthria0.0001906Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01945Least InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.00313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.006651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.0002162InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0002469InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.000257InformativeDirect
Mammalian Phenotype (MP)abnormal testis morphology0.0003663InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.0009707InformativeDirect
Mammalian Phenotype (MP)abnormal male meiosis0.000001626Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.00005849Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.00006287Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0001459Highly InformativeDirect
Mammalian Phenotype (MP)male infertility0.0002391Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell division variant0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Enzymes altering nucleic acid conformation0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 86 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ribosomal protein S5 domain 2-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]