SUPERFAMILY 1.75 HMM library and genome assignments server

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First domain of FERM family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Family:   First domain of FERM [ 54256] (6)


Family statistics
Genomes (133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 891 3,163 16
Proteins 891 3,163 16


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000839Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000001897Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.9162Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.01495Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0001613InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.006536Least InformativeInherited
Worm Phenotype (WP)cell development variant0.06141Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1167Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.1167Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1557Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3776Least InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.001889Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.002844Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01145Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.05574Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000008995InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00007322InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001075InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0001238InformativeDirect
Worm Phenotype (WP)cell component localization variant0.002081InformativeInherited
Worm Phenotype (WP)muscle cell attachment variant0.000002602Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00004773Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.003304Least InformativeInherited
Enzyme Commission (EC)Transferases0.01261Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.0000000277Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.003438Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000000000006018InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000001276InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 160 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]