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Cystatin/monellin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cystatin-like [ 54402] (7)
Superfamily:   Cystatin/monellin [ 54403] (6)
Families:   Monellin [ 54404]
  Cystatins [ 54407] (6)
  Cathelicidin motif [ 82592]
  Staphopain B, prodomain [ 117846]
  Latexin-like [ 142991]
  PepSY-like [ 159955]


Superfamily statistics
Genomes (684) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,738 13,811 30
Proteins 3,556 9,621 28


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000044330.000000000001791Least InformativeDirect
Biological Process (BP)biological regulation0.0064970.001454Least InformativeInherited
Biological Process (BP)single-organism cellular process0.92671Least InformativeInherited
Biological Process (BP)response to external stimulus0.000012890.000000000007011Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.00000017780Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000002460Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.8940.2759Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.99690.1292Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.021130.00002828Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.0032340.06092Moderately InformativeInherited
Biological Process (BP)defense response0.0012080Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.11160.1026Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.35240.001901Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00013640.2103Moderately InformativeInherited
Biological Process (BP)regulation of localization0.30210.0002985Moderately InformativeInherited
Biological Process (BP)cell activation0.00085170.000006127InformativeDirect
Biological Process (BP)cell death0.00000070750.0001397InformativeDirect
Biological Process (BP)negative regulation of cellular protein metabolic process0.00041160.00003781InformativeDirect
Biological Process (BP)negative regulation of molecular function0.00000012430.00000005861InformativeDirect
Biological Process (BP)regulation of hydrolase activity0.00000033530.0000002043InformativeDirect
Biological Process (BP)positive regulation of transport0.0036210.000001588InformativeInherited
Biological Process (BP)regulation of proteolysis0.0048370.0000107InformativeInherited
Biological Process (BP)regulation of catabolic process0.078770.1065InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.047260.0131InformativeInherited
Biological Process (BP)response to bacterium0.025210.005059InformativeInherited
Biological Process (BP)defense response to other organism0.13360.00003091InformativeInherited
Biological Process (BP)regulation of cell differentiation0.13460.8956InformativeInherited
Biological Process (BP)positive regulation of developmental process0.024330.559InformativeInherited
Biological Process (BP)interspecies interaction between organisms0.27670.5008InformativeInherited
Biological Process (BP)defense response to Gram-positive bacterium0.00046870.0004299Highly InformativeDirect
Biological Process (BP)regulation of lipid catabolic process0.0000840.00000008391Highly InformativeDirect
Molecular Function (MF)binding0.70571Least InformativeInherited
Molecular Function (MF)molecular function regulator00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.077210.0000000000008676Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme binding0.0037080.07387InformativeInherited
Molecular Function (MF)protease binding0.000000045180.000000006493Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase inhibitor activity0.000000010020.000007441Highly InformativeDirect
Cellular Component (CC)extracellular region part0.00000016020.00000000000002553Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000000000001791 Least Informative Direct
Biological Process (BP) biological regulation 0.001454 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0001426 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000007011 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0002985 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00002828 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.1026 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2759 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01832 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.001901 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1292 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.06092 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2103 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.06463 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.3667 Moderately Informative Inherited
Biological Process (BP) cell activation 0.000006127 Informative Direct
Biological Process (BP) immune response 0.00005124 Informative Direct
Biological Process (BP) cell death 0.0001397 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0000107 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00003781 Informative Direct
Biological Process (BP) secretion by cell 0.0008139 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00004267 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.00000005861 Informative Direct
Biological Process (BP) positive regulation of transport 0.000001588 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000008353 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00007427 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000002043 Informative Direct
Biological Process (BP) defense response to other organism 0.00003091 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.4398 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1239 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.05457 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3454 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5607 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.2957 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.1065 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.0131 Informative Inherited
Biological Process (BP) response to bacterium 0.005059 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5972 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.8956 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.559 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.5008 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9855 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01653 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001202 Informative Inherited
Biological Process (BP) regulation of growth 0.04386 Informative Inherited
Biological Process (BP) response to wounding 0.3276 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.06945 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1857 Informative Inherited
Biological Process (BP) regulation of immune response 0.4443 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) hemostasis 0.000001569 Highly Informative Direct
Biological Process (BP) coagulation 0.000001383 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 0.0004299 Highly Informative Direct
Biological Process (BP) regulation of lipid catabolic process 0.00000008391 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0004148 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000006491 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.001536 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.004607 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.05128 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.02199 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.03697 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.02998 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.001712 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.003683 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.007207 Highly Informative Inherited
Biological Process (BP) wound healing 0.5818 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.428 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0000000000008676 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.2528 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00001279 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000007479 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.02967 Informative Inherited
Molecular Function (MF) enzyme binding 0.07387 Informative Inherited
Molecular Function (MF) protease binding 0.000000006493 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000007441 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000001655 Highly Informative Direct
Molecular Function (MF) heme binding 0.000009662 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000001935 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000000002553 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.9679 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.08116 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.0000003457 Informative Direct
Cellular Component (CC) extracellular organelle 0.000000008727 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.000278 Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.0000001093 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.0000000005104Moderately InformativeDirect
Biological processImmunity0.0008907Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processChemotaxis0.0000008422InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationProtease0.007646Moderately InformativeInherited
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationThiol protease0.00000000001961InformativeDirect
Post-translational modificationHeparin-binding0.00000000006411InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationAntibiotic0.0000000000002559Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.00000000000001588InformativeDirect
Post-translational modificationAmidation0.0000000000981Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cystatin/monellin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cystatin/monellin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]