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MHC antigen-recognition domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MHC antigen-recognition domain [ 54451]
Superfamily:   MHC antigen-recognition domain [ 54452]
Family:   MHC antigen-recognition domain [ 54453] (12)


Family statistics
Genomes (65) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,875 69,430 190
Proteins 2,869 69,385 190


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01255Least InformativeInherited
Disease Ontology (DO)organ system cancer0.07263Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000001975Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0000004772Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.000001213Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00001072Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.00002395Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.0001528Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.0006289Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.00292Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03188Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.03351Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2779Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000006131InformativeDirect
Disease Ontology (DO)liver disease0.00000002503InformativeDirect
Disease Ontology (DO)Kawasaki disease0.0000001129InformativeDirect
Disease Ontology (DO)vasculitis0.000001332InformativeDirect
Disease Ontology (DO)hypotrichosis0.00004805InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0003129InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0003588InformativeDirect
Disease Ontology (DO)arthropathy0.007326InformativeInherited
Disease Ontology (DO)bullous skin disease0.01245InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.04475InformativeInherited
Disease Ontology (DO)eye disease0.06102InformativeInherited
Disease Ontology (DO)myeloid leukemia0.06957InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)Graves' disease0.00000000007061Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.00000005718Highly InformativeDirect
Disease Ontology (DO)psoriatic arthritis0.0000002171Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.0000009922Highly InformativeDirect
Disease Ontology (DO)spondylitis0.000008751Highly InformativeDirect
Disease Ontology (DO)neuromyelitis optica0.00001489Highly InformativeDirect
Disease Ontology (DO)pemphigus0.00001789Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.00002391Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.00003804Highly InformativeDirect
Disease Ontology (DO)hemochromatosis0.0000627Highly InformativeDirect
Disease Ontology (DO)vascular hemostatic disease0.00007335Highly InformativeDirect
Disease Ontology (DO)uveitis0.0001274Highly InformativeDirect
Disease Ontology (DO)rheumatic fever0.0002952Highly InformativeDirect
Disease Ontology (DO)thyroid gland disease0.001791Highly InformativeInherited
Disease Ontology (DO)neuromuscular disease0.02601Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.00000000002129InformativeDirect
Mode of Inheritance (MI)Heterogeneous0.00024InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.000242Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.02586Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07917Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1812Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2279Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2966Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3404Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.368Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4152Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6523Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.001367Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.004482Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.007458Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.04364Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.04721Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.05279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.08062Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.08229Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.08464Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.0873Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.09111Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.1051Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1189Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1247Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.19Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3313Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.3403Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual infection0.4933Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5093Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Nausea and vomiting0.00001413InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.00002068InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.00004434InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0.000103InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.0001064InformativeDirect
Phenotypic Abnormality (PA)Pain0.0002783InformativeDirect
Phenotypic Abnormality (PA)Edema0.0003166InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.0004795InformativeDirect
Phenotypic Abnormality (PA)Abnormal hair quantity0.006662InformativeInherited
Phenotypic Abnormality (PA)Stomatitis0.01125InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.09922InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.1374InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.2147InformativeInherited
Phenotypic Abnormality (PA)Arthralgia0.00000001604Highly InformativeDirect
Phenotypic Abnormality (PA)Abdominal pain0.0000009943Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pleura0.000001103Highly InformativeDirect
Phenotypic Abnormality (PA)Pericarditis0.000001237Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.00001131Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal sputum0.00001497Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.00001545Highly InformativeDirect
Phenotypic Abnormality (PA)Alopecia0.00005079Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.00006521Highly InformativeDirect
Phenotypic Abnormality (PA)Glomerulopathy0.0001Highly InformativeDirect
Phenotypic Abnormality (PA)Cough0.0001445Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pancreas physiology0.000204Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.0002401Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.0002736Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal C-reactive protein level0.0004941Highly InformativeDirect
Phenotypic Abnormality (PA)Diabetes insipidus0.0006147Highly InformativeDirect
Phenotypic Abnormality (PA)Chest pain0.0006625Highly InformativeDirect
Phenotypic Abnormality (PA)Skin ulcer0.0008316Highly InformativeDirect
Phenotypic Abnormality (PA)Hemiplegia/hemiparesis0.0009204Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000002049Least InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.000001876Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0.00002667Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0002401Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.07073Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3972Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6775Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.8042Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.0001337InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.0003967InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.0008012InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.0887InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.201InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.3194InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.3275InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.7941InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.0005559Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0.4588Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.2588Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.000356Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 92 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a MHC antigen-recognition domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]