SUPERFAMILY 1.75 HMM library and genome assignments server

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Colicin E3 immunity protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FKBP-like [ 54533] (3)
Superfamily:   Colicin E3 immunity protein [ 54552]
Families:   Colicin E3 immunity protein [ 54553]

Superfamily statistics
Genomes (14) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14 250 2
Proteins 14 250 2

Functional annotation
General category Processes_IC
Detailed category Transport

Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR003063 SSF54552 Protein matches
Abstract The cloacin immunity protein complexes with cloacin in equimolar quantities and inhibits it by binding with high affinity to the cloacin C-terminal catalytic domain. The immunity protein is relatively small, containing 85 amino acids.

An extra ribosome binding site has been found to precede the immunity gene on the polycistronic Clo DF13 mRNA [PubMed6253914], which perhaps accounts for the fact that, in cloacinogenic cells, more immunity protein than cloacin is synthesised [PubMed6253914]. Comparison of the complete amino acid sequence of the Clo DF13 immunity protein with that of the Col E3 and Col E6 immunity proteins reveals extensive similarities in primary structure, although Col E3 and Clo DF13 immunity proteins are exchangeable only to a low extent in vivo and in vitro [PubMed6253914].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Colicin E3 immunity protein domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Colicin E3 immunity protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]