SUPERFAMILY 1.75 HMM library and genome assignments server

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CBS-domain pair family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Family:   CBS-domain pair [ 54632] (20)


Family statistics
Genomes (2,213) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,965 30,214 29
Proteins 4,335 28,240 24


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3327Least InformativeInherited
Enzyme Commission (EC)Lyases0.2489Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006839Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001478Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003302InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1153Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.02697Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood ion concentration0.00216InformativeInherited
Phenotypic Abnormality (PA)Hypokalemia0.00004308Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2174Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4155Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.04906Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.06075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08606Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.006132InformativeInherited
Mammalian Phenotype (MP)abnormal glial cell morphology0.02765InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5055InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.3947Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.3947Least InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.00000000004939Highly InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.000000006847Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.00000001441Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.000312Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.5374Moderately InformativeInherited
Enzyme Commission (EC)Lyases0.6596Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000008902InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.005877InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0.01697InformativeInherited
Enzyme Commission (EC)Translocases0.04966InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses0.007059Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]