SUPERFAMILY 1.75 HMM library and genome assignments server

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Tetramerization domain of potassium channels family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Family:   Tetramerization domain of potassium channels [ 54701] (6)


Family statistics
Genomes (144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,409 3,973 12
Proteins 1,407 3,968 12


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2361Least InformativeInherited
Disease Ontology (DO)epilepsy0.0007959InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1611Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3907Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.0174Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cerebellum morphology0.01699InformativeInherited
Phenotypic Abnormality (PA)Myoclonus0.00000002212Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebellar atrophy0.0003246Highly InformativeDirect
Phenotypic Abnormality (PA)Focal dystonia0.0008192Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1808Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.003246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.4047Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.002432InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.005843InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to pharmacologically induced seizures0.0007514Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sleep behavior0.007558Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant0.0000008333Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0006586InformativeDirect
Fly Phenotype (FP)behavior defective0.002146InformativeInherited
Fly Phenotype (FP)sleep defective0.0000232Highly InformativeDirect
Fly Phenotype (FP)courtship behavior defective0.00003497Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.3669Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.5766Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9558Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.4545Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.5132Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.02306InformativeInherited
Xenopus ANatomical entity (XAN)eye0.4839InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.000007825Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.0001983Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0003373Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.009063Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.002695Moderately InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 36 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]