SUPERFAMILY 1.75 HMM library and genome assignments server

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dsRNA-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   dsRBD-like [ 54767] (5)
Superfamily:   dsRNA-binding domain-like [ 54768] (3)
Families:   Double-stranded RNA-binding domain (dsRBD) [ 54769] (12)
  The homologous-pairing domain of Rad52 recombinase [ 82645]
  Ribosomal S5 protein, N-terminal domain [ 54778]


Superfamily statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 17,227 78,579 40
Proteins 13,752 68,753 39


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.005954Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.0003041InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.01671Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2711Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.3325Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0003817InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0143InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.003439Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.008419Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04552Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.0003268Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.02636Moderately InformativeInherited
Worm Phenotype (WP)maintenance of gene silencing variant0.0000001877InformativeDirect
Worm Phenotype (WP)RNA expression variant0.00007097InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0002374InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.02776InformativeInherited
Worm Phenotype (WP)alae morphology variant0.00003104Highly InformativeDirect
Worm Phenotype (WP)neurite development variant0.00003331Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0005229Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)radiation resistance0.0007291Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.003864Least InformativeInherited
Fly Anatomy (FA)cell0.03823Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.357Least InformativeInherited
Fly Anatomy (FA)nervous system0.374Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4405Least InformativeInherited
Fly Anatomy (FA)adult0.445Least InformativeInherited
Fly Anatomy (FA)larva0.8764Least InformativeInherited
Fly Anatomy (FA)gonad0.0001247Moderately InformativeDirect
Fly Anatomy (FA)female-specific anatomical entity0.001475Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.03848Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.06047Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1001Moderately InformativeInherited
Fly Anatomy (FA)head0.1071Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1122Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1709Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2916Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.296Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0004686InformativeDirect
Fly Anatomy (FA)adult brain0.002603InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.00415InformativeInherited
Fly Anatomy (FA)central brain0.01463InformativeInherited
Fly Anatomy (FA)germarium0.02893InformativeInherited
Fly Anatomy (FA)interneuron0.03755InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.1059InformativeInherited
Fly Anatomy (FA)neuromere0.1211InformativeInherited
Fly Anatomy (FA)labral segment0.1622InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.2807InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001076Highly InformativeDirect
Fly Anatomy (FA)unilateral ACT relay interneuron0.0001156Highly InformativeDirect
Fly Anatomy (FA)neuroblast lineage clone0.0006045Highly InformativeDirect
Fly Anatomy (FA)cholinergic neuron0.0007623Highly InformativeDirect
Fly Anatomy (FA)mushroom body intrinsic neuron0.0008105Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.01186Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.3778InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a dsRNA-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the dsRNA-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]