SUPERFAMILY 1.75 HMM library and genome assignments server

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GroEL-intermediate domain like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   GroEL-intermediate domain like [ 54848]
Superfamily:   GroEL-intermediate domain like [ 54849] (2)
Families:   GroEL-like chaperone, intermediate domain [ 54850]
  Group II chaperonin (CCT, TRIC), intermediate domain [ 54853]


Superfamily statistics
Genomes (3,019) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,985 48,370 29
Proteins 9,794 47,832 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0InformativeDirect
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00001384Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00001857Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00002957Least InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000000178Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0000000811Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport variant0.0000007982Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00000109Moderately InformativeDirect
Worm Phenotype (WP)cell cycle variant0.00008506Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0005116Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.001271Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.002679Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.007024Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03807Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1092Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1671Moderately InformativeInherited
Worm Phenotype (WP)transgene expression increased0InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.000000000001234InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000000002187InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00000000003566InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.000000000995InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000000812InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0000001215InformativeDirect
Worm Phenotype (WP)vesicle organization variant0.0000001615InformativeDirect
Worm Phenotype (WP)male gonad development variant0.0000005398InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000006067InformativeDirect
Worm Phenotype (WP)protruding vulva0.000000632InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0000006998InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.000005686InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.0000117InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00001373InformativeDirect
Worm Phenotype (WP)sick0.0002441InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0003715InformativeDirect
Worm Phenotype (WP)life span variant0.0004044InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.0007154InformativeDirect
Worm Phenotype (WP)cell component localization variant0.003052InformativeInherited
Worm Phenotype (WP)mitosis variant0.119InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2246InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.4317InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7226InformativeInherited
Worm Phenotype (WP)oocytes small0.000000000000003586Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.000000000149Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.000000007376Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000003562Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000003179Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0000006441Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000003278Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00003376Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.00006893Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0003961Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organism subdivision0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.2883Least InformativeInherited
Fly Anatomy (FA)adult tagma0Moderately InformativeDirect
Fly Anatomy (FA)adult heart0.0000000004173InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.3045Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.06182Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.000001298InformativeDirect
Zebrafish Anatomy (ZA)skeletal muscle0.000004243InformativeDirect
Zebrafish Anatomy (ZA)muscle cell0.0000414InformativeDirect
Zebrafish Anatomy (ZA)myotome0.000000407Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.03685Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1655Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.0005483Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.004149Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.000002318InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0002389InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0003171InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0004216InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.00065InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0.0007083InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.004062InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.02629InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0004706Highly InformativeDirect
Xenopus DEvelopment stage (XDE)unspecified stage0.0008898Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000002576InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0001841InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.04421Least InformativeInherited
Enzyme Commission (EC)Isomerases0.0000002605Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0002409Moderately InformativeDirect
Enzyme Commission (EC)Isomerases altering macromolecular conformation2.574e-16InformativeDirect
Enzyme Commission (EC)Enzymes altering polypeptide conformation or assembly0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL-intermediate domain like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL-intermediate domain like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]