SUPERFAMILY 1.75 HMM library and genome assignments server

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GroEL-intermediate domain like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   GroEL-intermediate domain like [ 54848]
Superfamily:   GroEL-intermediate domain like [ 54849] (2)
Families:   GroEL-like chaperone, intermediate domain [ 54850]
  Group II chaperonin (CCT, TRIC), intermediate domain [ 54853]


Superfamily statistics
Genomes (3,019) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,985 48,370 29
Proteins 9,794 47,832 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0InformativeDirect
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000007922Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0000158Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00001585Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00003556Least InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.000000002159Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000005785Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000007462Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.000000976Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0002756Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.001202Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.001202Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.001206Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.001211Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.001331Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.002047Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.002588Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.002815Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1126Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1309Moderately InformativeInherited
Worm Phenotype (WP)transgene expression increased0InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000105InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000000002148InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00000000003498InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.0000000009463InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000000653InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.0000001134InformativeDirect
Worm Phenotype (WP)pigmentation variant0.000000417InformativeDirect
Worm Phenotype (WP)protruding vulva0.000000573InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000001181InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000002079InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.000002709InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.000005425InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.00001099InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00001338InformativeDirect
Worm Phenotype (WP)sick0.0002319InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0002819InformativeDirect
Worm Phenotype (WP)life span variant0.0003318InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00308InformativeInherited
Worm Phenotype (WP)mitosis variant0.09426InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2252InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2466InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.568InformativeInherited
Worm Phenotype (WP)oocytes small0.000000000000003551Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.000000000119Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.000000006533Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000003697Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000003136Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0000006353Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000003233Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00003421Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.00006575Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004285Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.3111Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult heart0.0000000004904InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.301Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.0135Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.06204Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.00000447InformativeDirect
Zebrafish Anatomy (ZA)muscle cell0.00004099InformativeDirect
Zebrafish Anatomy (ZA)myotome0.0000003858Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.03695Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1651Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.0006672Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.004184Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.000002413InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0002774InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0003716InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0004914InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0006739InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0.0007218InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.004086InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.02532InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0003994Highly InformativeDirect
Xenopus DEvelopment stage (XDE)unspecified stage0.0009088Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000002576InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0001841InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.04443Least InformativeInherited
Enzyme Commission (EC)Isomerases0.000000264Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0002422Moderately InformativeDirect
Enzyme Commission (EC)Isomerases altering macromolecular conformation2.561e-16InformativeDirect
Enzyme Commission (EC)Enzymes altering polypeptide conformation or assembly0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL-intermediate domain like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL-intermediate domain like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]