SUPERFAMILY 1.75 HMM library and genome assignments server

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HMA, heavy metal-associated domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   HMA, heavy metal-associated domain [ 55008]
Family:   HMA, heavy metal-associated domain [ 55009] (8)


Family statistics
Genomes (370) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 673 3,523 21
Proteins 542 3,183 20


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.2893Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.06075Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1719Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.00328Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.006651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.008504Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.02343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.003765InformativeInherited
Mammalian Phenotype (MP)postnatal lethality0.004871InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.00001087Highly InformativeDirect
Mammalian Phenotype (MP)pigmentation phenotype0.0001177Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality, incomplete penetrance0.0008782Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mineral level0.9226Highly InformativeInherited

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)alkaline pH resistance0.000004755Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.2446Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.3852Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.0000000001405Moderately InformativeDirect
Enzyme Commission (EC)Translocases0InformativeDirect
Enzyme Commission (EC)Catalysing the translocation of inorganic cations0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 33 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a HMA, heavy metal-associated domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]