SUPERFAMILY 1.75 HMM library and genome assignments server

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ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,034) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 43,765 304,454 43
Proteins 32,528 232,353 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000003708Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000007371Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.000002527Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0.000000000000002328InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000002234InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.00000008021InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01772Least InformativeInherited
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)brain disease0.0002238Moderately InformativeDirect
Disease Ontology (DO)schizophrenia0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.06922Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.09074Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0003927Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.004511Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02889Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0001832InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.004096InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0.000000003058Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception0.00002098Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0Moderately InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.1879Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2548Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.4398Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1304Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.143Moderately InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.01042InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.01101InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.01131InformativeInherited
Zebrafish Anatomy (ZA)trunk0.301InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic multipotent progenitor cell0.00000343Highly InformativeDirect
Zebrafish Anatomy (ZA)axial blood vessel0.0005209Highly InformativeDirect
Zebrafish Anatomy (ZA)artery0.0009744Highly InformativeDirect
Zebrafish Anatomy (ZA)trunk vasculature0.006565Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0.00006804Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.000167Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0001834Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.000319Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.894Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9792Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.00256Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.3148Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000008459InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000143InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000602InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.003412InformativeInherited
Enzyme Commission (EC)In linear amides0.9313InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0.9336InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0.00000000000002977Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0.00000000003393Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 37 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 37 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]