SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Adenylyl and guanylyl cyclase catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   Nucleotide cyclase [ 55073] (2)
Family:   Adenylyl and guanylyl cyclase catalytic domain [ 55074] (5)


Family statistics
Genomes (664) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,766 22,222 10
Proteins 4,565 19,310 10


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2323Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2619Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.004345Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.05236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1107Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1279Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.03182InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1279InformativeInherited
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.0003615Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vasodilation0.0005083Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.002986Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00000004391Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000002219Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)movement variant0.0114Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.07647Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.2269Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2881Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.00000000008968InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis variant0.00277Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping irregular0.1052Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.2104Highly InformativeInherited
Worm Phenotype (WP)positive chemotaxis defective0.2922Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.9878Highly InformativeInherited
Worm Phenotype (WP)negative chemotaxis variant1Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective0.00425Highly InformativeInherited

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)electrically active cell0Moderately InformativeDirect
Zebrafish Anatomy (ZA)neuron0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nucleotide cyclase domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]