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FMN-dependent nitroreductase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FMN-dependent nitroreductase-like [ 55468]
Superfamily:   FMN-dependent nitroreductase-like [ 55469] (2)
Families:   NADH oxidase/flavin reductase [ 55470] (8)
  Putative nitroreductase TM1586 [ 111078]


Superfamily statistics
Genomes (2,729) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,639 70,592 14
Proteins 10,055 67,121 14


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.18330.01062Least InformativeInherited
Biological Process (BP)biosynthetic process0.2430.1412Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.092450.4533Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.018150.00287Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.055930.5514Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.29820.08276Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.031480.005684Least InformativeInherited
Biological Process (BP)single-organism cellular process0.79531Least InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0064610.01216Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0040410.1184Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.012090.1202Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0058950.07757Moderately InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.00000077120.00000002994InformativeDirect
Biological Process (BP)water-soluble vitamin biosynthetic process0.0000045290.00000003881InformativeDirect
Biological Process (BP)cobalamin metabolic process0.0000000011620.000000000002268Highly InformativeDirect
Molecular Function (MF)binding0.6961Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0000000003860.000000000000003188Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.00047390.000001007Moderately InformativeDirect
Molecular Function (MF)anion binding0.00055310.000005318Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000054980.00000005769Moderately InformativeDirect
Molecular Function (MF)ribonucleotide binding0.000012250.000000001951InformativeDirect
Molecular Function (MF)FMN binding0.0000000000098660Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.08276 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01062 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1412 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.00287 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.4533 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5514 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.005684 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0.392 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01216 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1184 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.1202 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.07757 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001415 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.000001101 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001218 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.00000002994 Informative Direct
Biological Process (BP) water-soluble vitamin biosynthetic process 0.00000003881 Informative Direct
Biological Process (BP) cobalamin metabolic process 0.000000000002268 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000003487 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.000000000000003188 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000001007 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000005318 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000005769 Moderately Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000001951 Informative Direct
Molecular Function (MF) FMN binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.8052 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.926 Least Informative Inherited
Cellular Component (CC) membrane 0.1297 Least Informative Inherited
Cellular Component (CC) vesicle 0.08009 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.0002659 Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000008102 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasmic vesicle0.000121Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionPotassium0.000001154InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000415 SSF55469 Protein matches
Abstract

This family is involved in the reduction of nitrogen containing compounds. Members of this family utilise FMN as a cofactor and are often found to be homodimers. Possible characteristics include Oxygen-insensitive NAD(P)H nitroreductase (FMN-dependent nitroreductase) (Dihydropteridine reductase) and NADH dehydrogenase . A number of the proteins are described as oxidoreductases. They are primarily found in bacterial lineages though a number of eukaryotic homologs have been identified: Caenorhabditis elegans , Drosophila melanogaster , mouse and human . This protein is not found in photosynthetic eukaryotes. The sequences containing this entry in photosynthetic organisms are possible false positives.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FMN-dependent nitroreductase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the FMN-dependent nitroreductase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]