SUPERFAMILY 1.75 HMM library and genome assignments server

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Reprolysin-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Family:   Reprolysin-like [ 55519] (2)


Family statistics
Genomes (117) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 772 2,775 14
Proteins 771 2,768 14


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1696Least InformativeInherited
Disease Ontology (DO)breast carcinoma0.0002617InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.6217Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.2114Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.2878Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.4218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.2805InformativeInherited
Mammalian Phenotype (MP)double outlet right ventricle0.0001406Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.0004955Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.0006008Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle morphology0.005641Highly InformativeInherited
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.111Highly InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.1287Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.007821Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.03507Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000000002674Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.006671Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.03328Moderately InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.0005621Least InformativeDirect
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.000000000000001112Highly InformativeDirect
Xenopus DEvelopment stage (XDE)unfertilized egg stage0.0007307Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 92 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]