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Matrix metalloproteases, catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Family:   Matrix metalloproteases, catalytic domain [ 55528] (13)


Family statistics
Genomes (193) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,922 4,553 55
Proteins 1,912 4,516 55


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B0.00001043Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.00001043Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.057Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1116Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.00006466Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.00007594Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.0008824Moderately InformativeDirect
Disease Ontology (DO)artery disease0.003913Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.009329Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01355Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.06104Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.06976Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.1238Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.4037Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease0.0000002557InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0000003707InformativeDirect
Disease Ontology (DO)atherosclerosis0.00004546InformativeDirect
Disease Ontology (DO)scleroderma0.00008096InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.000473InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0006681InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.003076InformativeInherited
Disease Ontology (DO)eye disease0.01198InformativeInherited
Disease Ontology (DO)heart disease0.01375InformativeInherited
Disease Ontology (DO)urinary system cancer0.01604InformativeInherited
Disease Ontology (DO)malignant glioma0.01986InformativeInherited
Disease Ontology (DO)male reproductive organ cancer0.05004InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9101InformativeInherited
Disease Ontology (DO)myopathy1InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.0000001067Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.0000004072Highly InformativeDirect
Disease Ontology (DO)myopia0.000001628Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.000002784Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.000004014Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.00006041Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00006692Highly InformativeDirect
Disease Ontology (DO)bronchiectasis0.0002166Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.0002479Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0002515Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1246Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.8571Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1195Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.0745InformativeInherited
Phenotypic Abnormality (PA)Metaphyseal widening0.00006505Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.008448Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.02916Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.00002968Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.00436Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.0287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.04209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07201Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0728Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.08605Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.1251Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3223Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3803Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8414Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0000008347InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0002932InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0004147InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.002403InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.003571InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.005977InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.009829InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.01032InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01282InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.01524InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.02449InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.07364InformativeInherited
Mammalian Phenotype (MP)aortic aneurysm0.00001336Highly InformativeDirect
Mammalian Phenotype (MP)decreased angiogenesis0.00007636Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor morphology0.00008606Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0002773Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0.0004214Highly InformativeDirect
Mammalian Phenotype (MP)abnormal femur morphology0.000507Highly InformativeDirect
Mammalian Phenotype (MP)abnormal forelimb stylopod morphology0.0009421Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.008355Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long bone epiphyseal plate morphology0.01192Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.01552Highly InformativeInherited
Mammalian Phenotype (MP)abnormal maxilla morphology0.1576Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.4723Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7403Least InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0002982InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.02844InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 92 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]