SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)

Superfamily statistics
Genomes (456) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,438 41,145 94
Proteins 12,967 36,814 90

Functional annotation
General category Regulation
Detailed category Signal transduction

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001116Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0001827Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03907Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8738Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.000961InformativeDirect
Disease Ontology (DO)myeloid leukemia0.302InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000003482Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003699Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0005894InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.008669Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.0298Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6255Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00001377Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.000017Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.00005435Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1016Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4998Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular immune system morphology0.0000003331InformativeDirect
Phenotypic Abnormality (PA)Abnormality of B cell physiology0.000004177InformativeDirect
Phenotypic Abnormality (PA)Unusual CNS infection0.000006906InformativeDirect
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.007138InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01379InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00003249Highly InformativeDirect
Phenotypic Abnormality (PA)Fever0.00005211Highly InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.0003454Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.03048Highly InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.1666Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000003501Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000000006222Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1045Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1743Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.4784Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001059Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000002018Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0001477Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0006188Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.02191Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.02664Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03096Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03464Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07145Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.0754Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2449Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000001915InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001417InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000005482InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001161InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002422InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0008589InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.000924InformativeDirect
Mammalian Phenotype (MP)abnormal interferon level0.03205InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.04808InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.05889InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06233InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06776InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1473InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1513InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.191InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.24InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2761InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3572InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000004513Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.0001542Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003313Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004019Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0004753Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005286Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.000662Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.0008308Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.02326Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.02885Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.2734Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.274Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.4295Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00001106Moderately InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.000000000001326InformativeDirect
Worm Phenotype (WP)cell component localization variant0.0000000165InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000002267InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000004101InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0003447InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.00000000000001505Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0000000004877Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.0000317InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.01136Least InformativeInherited
Fly Anatomy (FA)adult0.01431Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01783Least InformativeInherited
Fly Anatomy (FA)nervous system0.1419Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6166Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.0002113Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0007636Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.002146Moderately InformativeInherited
Fly Anatomy (FA)gonad0.0185Moderately InformativeInherited
Fly Anatomy (FA)appendage0.05677Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.07798Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.08583Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1164Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1289Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1784Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1822Moderately InformativeInherited
Fly Anatomy (FA)head0.196Moderately InformativeInherited
Fly Anatomy (FA)thorax0.2518Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.2801Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5684Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.7687Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.869Moderately InformativeInherited
Fly Anatomy (FA)wing blade0.0009346InformativeDirect
Fly Anatomy (FA)ovariole0.001866InformativeInherited
Fly Anatomy (FA)tract0.005969InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.01161InformativeInherited
Fly Anatomy (FA)germline cyst0.03562InformativeInherited
Fly Anatomy (FA)male organism0.2419InformativeInherited
Fly Anatomy (FA)photoreceptor cell R70.00008636Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1436Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0004522InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.02095InformativeInherited
Zebrafish Anatomy (ZA)portion of organism substance0.003377Highly InformativeInherited
Zebrafish Anatomy (ZA)mononuclear phagocyte0.2029Highly InformativeInherited
Zebrafish Anatomy (ZA)professional antigen presenting cell0.3333Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.01296InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0009085Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.0000008425Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000001074Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000001065InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000001842InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00005793InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C2.561e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 73 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 73 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]