SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Family:   SH2 domain [ 55551] (34)


Family statistics
Genomes (151) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,490 17,735 94
Proteins 5,791 15,739 90


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000003398Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000292Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000009323InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0002255InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.00000000000001293Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001081Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0002563Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03269Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8423Moderately InformativeInherited
Disease Ontology (DO)myeloid leukemia0.2508InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000001686Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003455Highly InformativeDirect
Disease Ontology (DO)mumps0.0005333Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0006156Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.001391Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.006762Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.02381Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5754Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00001129Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00001489Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.00002739Moderately InformativeDirect
Phenotypic Abnormality (PA)Unusual infection0.0004746Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.08356Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.1653Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.1713Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.0000003385InformativeDirect
Phenotypic Abnormality (PA)Fever0.00004175InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.00315InformativeInherited
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.003664InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.01458InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.03109InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00001564Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of multiple cell lineages in the bone marrow0.00006428Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent skin infections0.00009875Highly InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.0003323Highly InformativeDirect
Phenotypic Abnormality (PA)Neutropenia0.000548Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.00000000095Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000000001362Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.001149Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.131Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2005Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.5322Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.9024Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001571Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000001088Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.000002392Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0005083Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.00345Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.005019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01704Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02312Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.04587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.06481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1324Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1595Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.3109Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00000000009131InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000001187InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000003192InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000005348InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.000752InformativeDirect
Mammalian Phenotype (MP)increased lymphocyte cell number0.0008413InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.004049InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.02045InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.02582InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.05696InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06425InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.1349InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.1888InformativeInherited
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.000000006206Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.000001593Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0001939Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0002095Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0002397Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0002831Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0004086Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.1159Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.5833Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.5833Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.8039Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0001223Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.0247Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00000000002861InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000005436InformativeDirect
Worm Phenotype (WP)cell component localization variant0.0000000788InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000001628InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0003745InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0000000000003241Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00000001015Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.00003382InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01227Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01239Least InformativeInherited
Fly Anatomy (FA)tagma0.0167Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.02303Least InformativeInherited
Fly Anatomy (FA)segment0.03429Least InformativeInherited
Fly Anatomy (FA)adult0.06591Least InformativeInherited
Fly Anatomy (FA)nervous system0.1589Least InformativeInherited
Fly Anatomy (FA)larva0.4724Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6264Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0008353Moderately InformativeDirect
Fly Anatomy (FA)female organism0.003407Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.005708Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01035Moderately InformativeInherited
Fly Anatomy (FA)appendage0.01612Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01638Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01864Moderately InformativeInherited
Fly Anatomy (FA)adult head0.03288Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04997Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.05572Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1283Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1351Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1933Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5379Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5772Moderately InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.00001691InformativeDirect
Fly Anatomy (FA)adult optic lobe neuron0.00004289InformativeDirect
Fly Anatomy (FA)adult peripheral nervous system0.0001027InformativeDirect
Fly Anatomy (FA)photoreceptor cell0.0002161InformativeDirect
Fly Anatomy (FA)sensory organ cell0.0002598InformativeDirect
Fly Anatomy (FA)female germline cyst0.0004035InformativeDirect
Fly Anatomy (FA)wing blade0.0006276InformativeDirect
Fly Anatomy (FA)adult head sensillum0.005812InformativeInherited
Fly Anatomy (FA)tract0.006167InformativeInherited
Fly Anatomy (FA)eye0.0818InformativeInherited
Fly Anatomy (FA)male organism0.2332InformativeInherited
Fly Anatomy (FA)somatic stem cell0.6001InformativeInherited
Fly Anatomy (FA)somatic cell of testis0.001535Highly InformativeInherited
Fly Anatomy (FA)germinal proliferation center0.02518Highly InformativeInherited
Fly Anatomy (FA)inner photoreceptor cell0.138Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1225Least InformativeInherited
Zebrafish Anatomy (ZA)immune system0.0003068InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic cell0.0003521InformativeDirect
Zebrafish Anatomy (ZA)motile cell0.006161InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.02047InformativeInherited
Zebrafish Anatomy (ZA)mononuclear phagocyte0.1998Highly InformativeInherited
Zebrafish Anatomy (ZA)blood cell0.2758Highly InformativeInherited
Zebrafish Anatomy (ZA)professional antigen presenting cell0.3381Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.01444InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0006479Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.000001697Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00000009064InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000007969InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000003513Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00006988Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 73 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]