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Acyl-CoA N-acyltransferases (Nat) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Acyl-CoA N-acyltransferases (Nat) [ 55728]
Superfamily:   Acyl-CoA N-acyltransferases (Nat) [ 55729] (10)
Families:   N-acetyl transferase, NAT [ 55730] (57)
  N-myristoyl transferase, NMT [ 55748]
  Autoinducer synthetase [ 75508] (2)
  FemXAB nonribosomal peptidyltransferases [ 82749] (3)
  Hypothetical protein cg14615-pa [ 103179]
  LFTR-like [ 143711]
  Ornithine decarboxylase antizyme-like [ 143714]
  AstA-like [ 143717]
  Aq 1966-like [ 143720]
  EF1021-like [ 160644] (3)


Superfamily statistics
Genomes (3,186) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 91,426 745,641 112
Proteins 88,374 723,864 104


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Amino-acid N-acetyltransferase0.0000001704Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3325Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle tone0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.071Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.09216Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1803Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.2311Moderately InformativeInherited
Phenotypic Abnormality (PA)Microcephaly0InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Global developmental delay0InformativeDirect
Phenotypic Abnormality (PA)Abnormal renal morphology0.03284InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.04478InformativeInherited
Phenotypic Abnormality (PA)Involuntary movements0.1603InformativeInherited
Phenotypic Abnormality (PA)Stereotypy0.000215Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the renal pelvis0.0002214Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cheek0.0003444Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal aggressive, impulsive or violent behavior0.000846Highly InformativeDirect
Phenotypic Abnormality (PA)Posteriorly rotated ears0.002173Highly InformativeInherited
Phenotypic Abnormality (PA)Low-set ears0.0126Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mandible0.02802Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)reproductive system development variant0.05147Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.0004352InformativeDirect
Worm Phenotype (WP)cell number increased0.01079InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 130 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA N-acyltransferases (Nat) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 130 hidden Markov models representing the Acyl-CoA N-acyltransferases (Nat) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]