SUPERFAMILY 1.75 HMM library and genome assignments server

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GAF domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   GAF domain-like [ 55781] (4)
Family:   GAF domain [ 55782] (7)


Family statistics
Genomes (1,630) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,876 23,035 11
Proteins 2,731 22,549 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1333Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1363Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2119Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.0241Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.03402Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.04041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1137Moderately InformativeInherited
Phenotypic Abnormality (PA)Obesity0.0006867InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0006954InformativeDirect
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.001888InformativeInherited
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.002301InformativeInherited
Phenotypic Abnormality (PA)Visual impairment0.008637InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.01522InformativeInherited
Phenotypic Abnormality (PA)Abnormal electroretinogram0.000033Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of retinal pigmentation0.0001503Highly InformativeDirect
Phenotypic Abnormality (PA)Hypogonadism0.0005686Highly InformativeDirect
Phenotypic Abnormality (PA)Glucose intolerance0.000644Highly InformativeDirect
Phenotypic Abnormality (PA)Reduced visual acuity0.0006954Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01376Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.004636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.03009Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2333Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.0004155InformativeDirect
Mammalian Phenotype (MP)decreased neuron number0.001108InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.001386InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.000002461Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye electrophysiology0.00007914Highly InformativeDirect
Mammalian Phenotype (MP)neurodegeneration0.006264Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)branch0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)fruit0.0001402InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.000003318InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000002006Least InformativeDirect
Enzyme Commission (EC)Transferases0.03967Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a GAF domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]