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DNA gyrase/MutL, N-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Family:   DNA gyrase/MutL, N-terminal domain [ 55879] (6)


Family statistics
Genomes (3,207) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,498 70,574 16
Proteins 8,498 70,571 16


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.163Least InformativeInherited
Disease Ontology (DO)genetic disease0.006932Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.06549Moderately InformativeInherited
Disease Ontology (DO)male reproductive organ cancer0.0001106InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.0001629InformativeDirect
Disease Ontology (DO)large intestine cancer0.0009677InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.09177Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.0952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.114Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1199Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1457Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.147Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7745Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.005091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.006633Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.006847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.008326Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.009261Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.009577Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01018Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.01096Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.01215Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.01614Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.01841Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.01959Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.01989Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.02205Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.02576Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.03854Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.03929Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.06867Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.087Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.0000000437InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ovary0.000008072InformativeDirect
Phenotypic Abnormality (PA)Anorectal anomaly0.000009082InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.00001081InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.00001827InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.00002419InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.00006838InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.00007382InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.00008067InformativeDirect
Phenotypic Abnormality (PA)Nausea and vomiting0.0001163InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.0001471InformativeDirect
Phenotypic Abnormality (PA)Impairment in personality functioning0.0002875InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0.0003897InformativeDirect
Phenotypic Abnormality (PA)Flexion contracture0.0005479InformativeDirect
Phenotypic Abnormality (PA)Pain0.0007168InformativeDirect
Phenotypic Abnormality (PA)Abnormal intestine morphology0.0007831InformativeDirect
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.00208InformativeInherited
Phenotypic Abnormality (PA)Visual impairment0.002249InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.00382InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.00482InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02619InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uterus0.06035InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.00000000003377Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.0000000001714Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.0000000004664Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000000007196Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000000001293Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.000000001549Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.000000002567Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastoma0.000000003Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the rectum0.000000003Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000000003493Highly InformativeDirect
Phenotypic Abnormality (PA)Basal cell carcinoma0.000000007032Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.00000001299Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.00000003018Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.00000003649Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.0000000437Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00000004772Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00000006184Highly InformativeDirect
Phenotypic Abnormality (PA)Endometrial carcinoma0.0000001047Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.0000002432Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.000000311Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.0000005031Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.000000673Highly InformativeDirect
Phenotypic Abnormality (PA)Hallucinations0.0000007419Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0000008971Highly InformativeDirect
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.000001083Highly InformativeDirect
Phenotypic Abnormality (PA)Visual field defect0.000001888Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.000002131Highly InformativeDirect
Phenotypic Abnormality (PA)Hemiplegia/hemiparesis0.000004142Highly InformativeDirect
Phenotypic Abnormality (PA)Malabsorption0.000004725Highly InformativeDirect
Phenotypic Abnormality (PA)Developmental regression0.00001827Highly InformativeDirect
Phenotypic Abnormality (PA)Anxiety0.00002016Highly InformativeDirect
Phenotypic Abnormality (PA)Constipation0.00002155Highly InformativeDirect
Phenotypic Abnormality (PA)Depressivity0.00002841Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.00002963Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pyramidal sign0.00003365Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.00007932Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.0001201Highly InformativeDirect
Phenotypic Abnormality (PA)Dysarthria0.0002044Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01945Least InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.00313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.006651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.0002163InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0002469InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.000257InformativeDirect
Mammalian Phenotype (MP)abnormal testis morphology0.0003662InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.0009708InformativeDirect
Mammalian Phenotype (MP)abnormal male meiosis0.000001623Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.00005843Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.00006282Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0001459Highly InformativeDirect
Mammalian Phenotype (MP)male infertility0.000239Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Enzymes altering nucleic acid conformation0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]