SUPERFAMILY 1.75 HMM library and genome assignments server

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The spindle assembly checkpoint protein mad2 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   The spindle assembly checkpoint protein mad2 [ 56018]
Superfamily:   The spindle assembly checkpoint protein mad2 [ 56019]
Family:   The spindle assembly checkpoint protein mad2 [ 56020]

Family statistics
Genomes (448) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 547 1,455 5
Proteins 546 1,454 5

Mouse Phenotype (MP)

show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01945Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0.00313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.006651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.0002163InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0002469InformativeDirect
Mammalian Phenotype (MP)abnormal testis morphology0.0003662InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.0009708InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.141InformativeInherited
Mammalian Phenotype (MP)abnormal oogenesis0.000001508Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.000003536Highly InformativeDirect
Mammalian Phenotype (MP)arrest of spermatogenesis0.000004748Highly InformativeDirect
Mammalian Phenotype (MP)abnormal testis weight0.00001884Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.00005843Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.00006282Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0001459Highly InformativeDirect
Mammalian Phenotype (MP)male infertility0.000239Highly InformativeDirect

Document: MP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Mouse Phenotype (MP) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a The spindle assembly checkpoint protein mad2 domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Mouse Phenotype (MP) · Arabidopsis Plant Ontology (AP) · Internal database links ]