SUPERFAMILY 1.75 HMM library and genome assignments server

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SMAD MH1 domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SMAD MH1 domain [ 56365]
Superfamily:   SMAD MH1 domain [ 56366]
Family:   SMAD MH1 domain [ 56367]


Family statistics
Genomes (145) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 912 2,712 2
Proteins 910 2,706 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)urinary system disease0.001217Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01347Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.03912Moderately InformativeInherited
Disease Ontology (DO)glomerulonephritis0.0000019InformativeDirect
Disease Ontology (DO)scleroderma0.0001326InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.09234Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.00794Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.05242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.05684Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.0005874InformativeDirect
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.002811InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.004InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.01964InformativeInherited
Phenotypic Abnormality (PA)Aortic dissection0.0000002494Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.00002943Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0002309Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.004737Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.008769Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.009176Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02336Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000001514Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.000006927Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.00002061Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.00002989Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.00005917Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0001253Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.0007287Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.009361Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.000001094InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.000002105InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.00002693InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0002269InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.0005269InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.001005InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.009122InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.04122InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.1758InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.2761InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal body size0.3067InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8188InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal axis patterning0.00000001861Highly InformativeDirect
Mammalian Phenotype (MP)abnormal follicle stimulating hormone level0.0000003114Highly InformativeDirect
Mammalian Phenotype (MP)increased reproductive system tumor incidence0.000002581Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.000003423Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.000007688Highly InformativeDirect
Mammalian Phenotype (MP)abnormal chorioallantoic fusion0.00001316Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovarian folliculogenesis0.00002987Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.00003581Highly InformativeDirect
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.00003978Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0005147Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0005662Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system development0.000626Highly InformativeDirect
Mammalian Phenotype (MP)internal hemorrhage0.001562Highly InformativeInherited
Mammalian Phenotype (MP)increased alimentary system tumor incidence0.01125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal oogenesis0.04987Highly InformativeInherited
Mammalian Phenotype (MP)abnormal female germ cell morphology0.05191Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0005098Least InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000572Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000572Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00005749Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.00005779Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.00006234Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.000101Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.00689Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.01267Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.05511Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3593Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.583Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0000005082InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.000002042InformativeDirect
Worm Phenotype (WP)tail morphology variant0.00000631InformativeDirect
Worm Phenotype (WP)male morphology variant0.000007712InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.00001068InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.00001413InformativeDirect
Worm Phenotype (WP)head movement variant0.00001684InformativeDirect
Worm Phenotype (WP)fat content variant0.00001716InformativeDirect
Worm Phenotype (WP)directionality variant0.00002627InformativeDirect
Worm Phenotype (WP)body bend variant0.00003908InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0006184InformativeDirect
Worm Phenotype (WP)body posture variant0.001671InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.006354InformativeInherited
Worm Phenotype (WP)small0.08594InformativeInherited
Worm Phenotype (WP)male tail morphology variant0.0000003684Highly InformativeDirect
Worm Phenotype (WP)short0.000002513Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.000004246Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000004789Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.000008552Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.000008769Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.000008769Highly InformativeDirect
Worm Phenotype (WP)dauer formation variant0.00001204Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.00001757Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.00001872Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.00003339Highly InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.03902Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)size defective0InformativeDirect
Fly Phenotype (FP)decreased cell number0InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)abdomen0Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult external thorax0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.006536Moderately InformativeInherited
Fly Anatomy (FA)female organism0.01152Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01931Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.07683Moderately InformativeInherited
Fly Anatomy (FA)imaginal disc0InformativeDirect
Fly Anatomy (FA)cuticle0InformativeDirect
Fly Anatomy (FA)wing blade0InformativeDirect
Fly Anatomy (FA)egg0.0008087InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.001396InformativeInherited
Fly Anatomy (FA)cell component0.007353InformativeInherited
Fly Anatomy (FA)germline cell0.0171InformativeInherited
Fly Anatomy (FA)wing disc0Highly InformativeDirect
Fly Anatomy (FA)wing vein0Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell0.000002735Highly InformativeDirect
Fly Anatomy (FA)bouton0.0005046Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.05095Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0.09575Moderately InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.0001275InformativeDirect
Zebrafish Anatomy (ZA)motile cell0.01013InformativeInherited
Zebrafish Anatomy (ZA)immune system0.01452InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.07589InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0911InformativeInherited
Zebrafish Anatomy (ZA)floor plate0.00000001943Highly InformativeDirect
Zebrafish Anatomy (ZA)intermediate cell mass of mesoderm0.000008804Highly InformativeDirect
Zebrafish Anatomy (ZA)mononuclear phagocyte0.00006202Highly InformativeDirect
Zebrafish Anatomy (ZA)professional antigen presenting cell0.00007955Highly InformativeDirect
Zebrafish Anatomy (ZA)median fin fold0.0009871Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.1219Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0004634Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.1373Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.00000186InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0001942InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.000199InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0003841InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.000473InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0005943InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000648InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.04621InformativeInherited
Xenopus ANatomical entity (XAN)ciliated cell0.0000007548Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00001146Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD MH1 domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]