SUPERFAMILY 1.75 HMM library and genome assignments server

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Fibrinogen C-terminal domain-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Fibrinogen C-terminal domain-like [ 56495]
Superfamily:   Fibrinogen C-terminal domain-like [ 56496]
Family:   Fibrinogen C-terminal domain-like [ 56497] (2)


Family statistics
Genomes (136) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,650 10,260 21
Proteins 3,598 10,006 21


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.06994Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.00317InformativeInherited
Disease Ontology (DO)congenital afibrinogenemia0.0000002736Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.1009Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2228Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.31Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.384Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4544Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4811Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4881Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6337Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.02341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.04012Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.08583Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.08858Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.09926Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.172Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.2184Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.2766Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.00001129InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.0002247InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0002922InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation0.0135InformativeInherited
Phenotypic Abnormality (PA)Edema0.05074InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.05172InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.1161InformativeInherited
Phenotypic Abnormality (PA)Splenic rupture0.000000004439Highly InformativeDirect
Phenotypic Abnormality (PA)Menometrorrhagia0.00000006839Highly InformativeDirect
Phenotypic Abnormality (PA)Spontaneous abortion0.00007789Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the common coagulation pathway0.0000856Highly InformativeDirect
Phenotypic Abnormality (PA)Joint swelling0.00009827Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.2721Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Fibrinogen C-terminal domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]