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Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Acyl-CoA dehydrogenase NM domain-like [ 56644]
Superfamily:   Acyl-CoA dehydrogenase NM domain-like [ 56645] (2)
Family:   Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [ 56646] (9)


Family statistics
Genomes (1,557) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,391 76,190 19
Proteins 8,381 76,134 19


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.001184Moderately InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0.000000000000006834Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.01036Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01305Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.01862Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.02054Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.442Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.00001362Moderately InformativeDirect
Phenotypic Abnormality (PA)Muscular hypotonia0.000399Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.002194Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.02449Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1616Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1718Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2015Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.3169Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3519Moderately InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.00000000001937InformativeDirect
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.0000001073InformativeDirect
Phenotypic Abnormality (PA)Acidosis0.000004855InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.00002631InformativeDirect
Phenotypic Abnormality (PA)Nausea and vomiting0.001884InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.003856InformativeInherited
Phenotypic Abnormality (PA)Abnormal liver morphology0.008497InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.01233InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.01785InformativeInherited
Phenotypic Abnormality (PA)Abnormal myocardium morphology0.01988InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.0204InformativeInherited
Phenotypic Abnormality (PA)Pain0.0235InformativeInherited
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.02715InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.135InformativeInherited
Phenotypic Abnormality (PA)Abnormality of mitochondrial metabolism0.0000003674Highly InformativeDirect
Phenotypic Abnormality (PA)Vomiting0.0000004484Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperammonemia0.0000008849Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic steatosis0.00002084Highly InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.00008666Highly InformativeDirect
Phenotypic Abnormality (PA)Hypothermia0.0001123Highly InformativeDirect
Phenotypic Abnormality (PA)Sudden cardiac death0.0003289Highly InformativeDirect
Phenotypic Abnormality (PA)Ketosis0.0007785Highly InformativeDirect
Phenotypic Abnormality (PA)Organic aciduria0.002754Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating carnitine concentration1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005994Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0000003261InformativeDirect
Mammalian Phenotype (MP)hepatic steatosis0.00000008216Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001215Least InformativeInherited
Worm Phenotype (WP)fat content variant0.0000002486InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.0000903Moderately InformativeDirect
Xenopus ANatomical entity (XAN)muscle0.000004066InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.02139InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.002175Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA dehydrogenase NM domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]