SUPERFAMILY 1.75 HMM library and genome assignments server

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DNA polymerase I family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   DNA/RNA polymerases [ 56671]
Superfamily:   DNA/RNA polymerases [ 56672] (6)
Family:   DNA polymerase I [ 56673] (4)


Family statistics
Genomes (3,100) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,342 38,694 36
Proteins 5,326 38,641 36


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.472Least InformativeInherited
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0.000008909InformativeDirect
Enzyme Commission (EC)Ribonuclease H0.000000001003Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.008791Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.05019Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.0007405InformativeDirect
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.03907InformativeInherited
Phenotypic Abnormality (PA)Hypogonadism0.00006245Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01278Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01397Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02226Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2574Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.0009856Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal B cell morphology0.004142Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.02397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.06245Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1987Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.000007013InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0002074InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0.0004999InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.003008InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.3155InformativeInherited
Mammalian Phenotype (MP)increased sarcoma incidence0.00002408Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.05227Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.05227Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.09141Least InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.003641Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.01233Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.03902Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001782InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.0004966InformativeDirect
Worm Phenotype (WP)nuclear morphology variation early emb0.00001805Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.2278Least InformativeInherited
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)mutation frequency0.00003403Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide accumulation0.0009777Highly InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.3622Moderately InformativeInherited
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 49 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DNA/RNA polymerases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]