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Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,243 3,727 29
Proteins 1,236 3,700 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0006392Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5044Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.002943Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.003228Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.005091Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.006546Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.0001969InformativeDirect
Disease Ontology (DO)carcinoma0.0002382InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.04342InformativeInherited
Disease Ontology (DO)viral infectious disease0.09014InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.00000577Highly InformativeDirect
Disease Ontology (DO)Graves' disease0.000145Highly InformativeDirect
Disease Ontology (DO)osteosarcoma0.0002952Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.001687Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.001896Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.08894Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1726Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.000849Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001391Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.001483Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.001519Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.02367Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.02857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03268Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.04734Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.2034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2143Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2597Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3673Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.7302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.00004562InformativeDirect
Mammalian Phenotype (MP)abnormal T cell physiology0.0003998InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.000567InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.002654InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.002978InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.003868InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.01616InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.04628InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.0655InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.2051InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.352InformativeInherited
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.000004319Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0001205Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0002518Highly InformativeDirect
Mammalian Phenotype (MP)absent germ cells0.0005241Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell apoptosis0.0006308Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovarian follicle morphology0.0006871Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0008568Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gametes0.007869Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.01261Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]